Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion: A Prospective Multicenter Registry Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- modified Rankin Scale at 90 days
研究概览
简要总结
This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy evaluation and prognostic prediction of the LVO patients with low NIHSS.
详细描述
It was reported that about two third of the stoke patients might present with minor or mild stroke symptoms. 20-40% of those minor stroke patients had large vessel occlusion (LVO). AIS patients with LVO and low NIHSS are common and has been associated with early neurological deterioration and worse outcomes. Until now, the best therapy strategy for the acute stoke patients with minor stroke and large vessel occlusion is unknown. Thus, we sought to (1) explore the potential predictors of acute neurological deterioration and 90-day clinical outcome; (2) and evaluate the best therapy strategy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years or older
- •Acute ischemic stroke patients of NIHSS 0-5 with 24 hours after onset
- •Proximal intracranial artery occlusion on NCCT/CTA or MRI/MRA showing occlusion of the intracranial ICA, M1, or proximal M2 vessel
- •Baseline ASPECTS ≥6 or infarct Core Volume of < 70 on NCCT/DWI/CTP
排除标准
- •Any sign of intracranial hemorrhage on baseline CT/MR;
- •Seizures at stroke onset
- •Baseline blood glucose of <2.78 mmol or >22.20 mmol, or platelet count < 100,000/uL or serum creatinine levels > 3.0 mg/dL
- •Participation in any investigational study in the previous 30 days
结局指标
主要结局
modified Rankin Scale at 90 days
时间窗: 90 days
modified Rankin Scale at 90 days
acute neurological deterioration
时间窗: 24 hours
It is neurological deterioration of presumed ischemic origin with an NIHSS score increase of 4 points or more within the 24 hours after onset.
次要结局
- Incidence of symptomatic intracerebral hemorrhage(2-3 days)
- patients with good outcome comparing the two treatment groups(90 days)
研究者
Jinhua Zhang
Prof.
Sir Run Run Shaw Hospital