Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion: A Prospective Multicenter Registry Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke, Acute
- Sponsor
- Sir Run Run Shaw Hospital
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- modified Rankin Scale at 90 days
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy evaluation and prognostic prediction of the LVO patients with low NIHSS.
Detailed Description
It was reported that about two third of the stoke patients might present with minor or mild stroke symptoms. 20-40% of those minor stroke patients had large vessel occlusion (LVO). AIS patients with LVO and low NIHSS are common and has been associated with early neurological deterioration and worse outcomes. Until now, the best therapy strategy for the acute stoke patients with minor stroke and large vessel occlusion is unknown. Thus, we sought to (1) explore the potential predictors of acute neurological deterioration and 90-day clinical outcome; (2) and evaluate the best therapy strategy.
Investigators
Jinhua Zhang
Prof.
Sir Run Run Shaw Hospital
Eligibility Criteria
Inclusion Criteria
- •Aged 18 years or older
- •Acute ischemic stroke patients of NIHSS 0-5 with 24 hours after onset
- •Proximal intracranial artery occlusion on NCCT/CTA or MRI/MRA showing occlusion of the intracranial ICA, M1, or proximal M2 vessel
- •Baseline ASPECTS ≥6 or infarct Core Volume of \< 70 on NCCT/DWI/CTP
Exclusion Criteria
- •Any sign of intracranial hemorrhage on baseline CT/MR;
- •Seizures at stroke onset
- •Baseline blood glucose of \<2.78 mmol or \>22.20 mmol, or platelet count \< 100,000/uL or serum creatinine levels \> 3.0 mg/dL
- •Participation in any investigational study in the previous 30 days
Outcomes
Primary Outcomes
modified Rankin Scale at 90 days
Time Frame: 90 days
modified Rankin Scale at 90 days
acute neurological deterioration
Time Frame: 24 hours
It is neurological deterioration of presumed ischemic origin with an NIHSS score increase of 4 points or more within the 24 hours after onset.
Secondary Outcomes
- Incidence of symptomatic intracerebral hemorrhage(2-3 days)
- patients with good outcome comparing the two treatment groups(90 days)