NCT01237834CompletedNot Applicable
Physiological Responses in Tobacco Chippers (Non Nicotine-dependent Light Smokers)
Oregon Health and Science University1 site in 1 country178 target enrollmentStarted: November 2010Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 178
- Locations
- 1
- Primary Endpoint
- Electroencephalography
Study Overview
Brief Summary
This study will analyze a series of biological and behavioral markers in different populations of smokers. The study groups will differ in their cigarette consumption and level of nicotine dependence. This analysis will help to identify factors that might be important for smoking behavior and nicotine addiction. The results from this study will contribute to improve campaigns for smoking prevention and treatments for smoking cessation.
Study Design
- Study Type
- Observational
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 25 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy adults
- •age 25-55
Exclusion Criteria
- •alcohol or drug addiction
- •unstable significant medical problems
- •neurologic disease
- •medications known to affect CNS function or impact physiologic parameters measured in the study
- •significant visual impairment
- •breath carbon monoxide (BCO) level of less than 10 ppm for smokers
- •breath carbon monoxide (BCO) level of more than 5 ppm for non-smokers
- •for heavy regular smokers: erratic smoking history (i.e. they must have smoked an average of 15 cigarettes daily for at least one year)
Outcomes
Primary Outcomes
Electroencephalography
Time Frame: Changes from baseline during a hard cognitive task
Electroencephalography will be measured during performance on a hard cognitive task.
Secondary Outcomes
- Salivary cortisol(Changes from baseline during performance on a hard cognitive task)
Investigators
Barry S. Oken
MD
Oregon Health and Science University
Study Sites (1)
Loading locations...
Similar Trials
Completed
Phase 2
Nicotine and Sensorimotor Replacement for Smoking in Smokers With SchizophreniaTobacco Use DisorderSchizophreniaNCT01213524Brown University75
Completed
Phase 1
Neurobiology of Nicotine and Non-nicotine Components of Tobacco AddictionSmokingNCT01056926Duke University147
Completed
Not Applicable
Development of Biomarkers of Effect From Chronic Tobacco UsageCigarette SmokingNCT01923402R.J. Reynolds Tobacco Company120
Terminated
Phase 2
Neuro Biomarkers of Smoking BehaviorSmoking CessationNCT03811951University of Illinois at Chicago4
Completed
Not Applicable
Tobacco Exposure and Influencing Factors of Smoking Cessation Among Chronic Kidney Disease PatientsSmoking CessationNCT06303089Sun Yat-sen University567