Evaluation of the Difference in Expression of the Mu Type 1 Opioid Receptor and of the Markers of Its Activation (Cyclic Adenosine Monophosphate and Protein Kinase A) in Colorectal Cancer. Case-control Study in Patients With Tumor Recurrence Versus Disease-free Patients at 5 Years.
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- MOR-1 expression by polymerase chain reaction (RT-qPCR) in tumor tissue and adjacent healthy tissue.
研究概览
简要总结
Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery.
详细描述
Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery. Period January 2010-December 2014. Patients must have had at least 5 years of follow-up to define disease-free survival. From the cohort of patients previously studied in our center by immunohistochemistry, 31 we will select 10 cases with recurrence by random sampling and we will match 10 controls by leveling the propensity score (propensity score matching).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 18 years of age.
- •Colorectal surgery scheduled between January 2010 - December
- •Stage II or III colon or rectum neoplasm (T3 / T4 N + M0).
排除标准
- •Neoplasia of colon or rectum in Stage I or Stage IV.
- •Non-oncological colorectal surgery.
- •Urgent surgery
结局指标
主要结局
MOR-1 expression by polymerase chain reaction (RT-qPCR) in tumor tissue and adjacent healthy tissue.
时间窗: Day 1
次要结局
- Cancer-free survival 5 years after surgery (disease-free survival-DFS).(Day 1)
- Degree of MOR-1 activation measured by immunohistochemistry through cAMP and PKA levels.(Day 1)
- MOR-1 expression by immunohistochemistry in tumor tissue and adjacent healthy tissue.(Day 1)
研究者
Oscar Diaz-Cambronero
Principal Investigator of Anesthesiology
Hospital Universitario La Fe