Is opioid free anaesthesia better than opioid anaesthesia for post operative recovery?

Not yet recruiting

Conditions: Calculus of gallbladder without cholecystitis, (2) ICD-10 Condition: O||Medical and Surgical,

Brief Summary: Opioid free anaesthesia is an anaesthetic technique where opioids are not used in the intraoperative period, by either systemic, neuraxial or intracavitary route. By avoiding the use of opioids in the perioperative period, the number of opioid related side effects are reduced.

Recently, multimodal analgesia techniques are becoming the basis of successful fast track surgery. These multidrug regimens aim at decreasing postoperative pain and intraoperative and postoperative opioid related adverse effects, thus hastening recovery. A multimodal approach allows reduction of the dose of each individual drug and exploits the synergistic effect among drugs, thereby reducing their side effect.

Thus, we decided to compare the effect of opioid free and opioid anaesthesia on postoperative recovery in patients undergoing laparoscopic cholecystectomy.

Recruitment & Eligibility

Inclusion Criteria

American Society of Anaesthesiologists (ASA) Physical Status Grade I-II.

Exclusion Criteria

1.Patients with AV block or severe bradycardia 2.Patients having BMI >30 kg/m2 3.Patients with allergy to any of the study drugs 4.Patients with cardiac, renal, hepatic and psychiatric illness.
5.H/o chronic use of opioid analgesic/ chronic steroids/ NSAIDS/ or any chronic drug therapy 6.H/o alcohol abuse 7.Patients who are pregnant or are breastfeeding 8.Patients with decreased autonomic control- elderly, diabetic, chronic hypertension, severe cardiac disease, on drugs like beta blockers or calcium channel blockers 9.Patient refusal.

Primary Outcome Measures

Name	Time	Method
Difference in postoperative recovery using QoR-40 score 24 hours after surgery.	24 hours after surgery.

Secondary Outcome Measures

Name	Time	Method
Postoperative VAS scores
Requirement of postoperative analgesics in the first 24 hours after surgery	over first 24 hours after surgery
Any intraoperative bradycardia, hypotension, tachycardia, or hypertension	at any point of time intraoperatively
Sedation score in PACU	on arrival at Post Aanaesthesia Care Unit (PACU)
Time for readiness for discharge from PACU (PADSS score)	0 min, 15 mins, 30 mins, 45 mins, 60 mins, 1 hour 15 mins, 1 hour 30 mins, 1 hour 45 mins, 2 hours in PACU
Postoperative opioid related side effects	within 24 hours of postoperative period

Locations (1): Lok Nayak Hospital
🇮🇳
Central, DELHI, India
Lok Nayak Hospital
🇮🇳Central, DELHI, India
Dr Geeta Chauhan
Principal investigator
8377936347
anesthesia.geeta.2020@gmail.com