Exercise Training in Asthma

Not Applicable

Terminated

• Conditions: Asthma
• Interventions: Other: Exercise training

• Registration Number: NCT00820716
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The aim of the study is to compare two methods of exercise training: alternate load versus constant load realized at moderate or high intensities, in order to define the interests and the limits of each one of these two methods. The finality is to make possible to the expert to choose what exercise training induces the best results quickly and to make its choice according to the therapeutic objectives which it lays down.We also evaluate the effects of these exercises training on the vagal response and the bronchial tone of the asthmatics. From a clinical point of view, a close attention will be paid to the effects of these exercises training on the control of asthma and the quality of life of the subjects

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-01-09
• Study First Submitted QC: 2009-01-09
• Study First Posted: 2009-01-12
• Study Start: 2009-09-21
• Primary Completion: 2010-10-15
• Study Completion: 2010-10-15
• Status Verified: 2011-08
• Last Update Submitted: 2020-07-09
• Last Update Posted: 2020-07-14

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• 18 to 45 years old
• mild to moderate persistent asthma (GINA classification)
• stabilized asthma
• physical activity level between 5 and 11 (Baecke and coll, 1982)
• no contra-indication for physical training

Exclusion Criteria

• cardiovascular pathology
• metabolic pathology
• traumatic pathology
• BMI≥30
• tobacco
• diabetes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CC	Exercise training	Exercise training with constant load
CA	Exercise training	Exercise training with alternate load

Primary Outcome Measures

Name	Time	Method
Maximal power output (Pmax)	At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training
Maximal oxygen consumption (VO2max)	At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training

Secondary Outcome Measures

Name	Time	Method
Exhaled NO (eNO)	At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training
Heart rate variability	At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training
Force Expiratory Volume in one second (FEV1)	At T-1 = eight weeks before training - At T0 = beginning of training - At T1 = eight weeks after training

Trial Locations

Locations (2)

Service de Physiologie et d'Explorations Fonctionnelles - Pôle de Pathologie Thoracique - Nouvel Hôpital Civil; 🇫🇷 Strasbourg, France

Service de Pneumologie - Pôle de Pathologie Thoracique - Nouvel Hôpital Civil; 🇫🇷 Strasbourg, France