Correlation and Comparison Analyses of CARG, G8, and Frailty Tests in Predicting Chemotherapy-Associated Toxicity: A Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Geriartric Form Results and Chemotherapy Side Effects
研究概览
简要总结
This prospective observational study aims to evaluate and compare the effectiveness of three geriatric assessment tools-CARG (Cancer and Aging Research Group score), G8 screening tool, and Frailty Scale-in predicting chemotherapy-related toxicity (CRT) in cancer patients aged 65 years and older. A total of at least 100 patients receiving standard chemotherapy (excluding hematologic malignancies and immunotherapy) at Çanakkale University Medical Faculty Oncology Clinic will be assessed prior to treatment initiation. Each participant will undergo baseline evaluations including G8, CARG, and Frailty assessments. The study will analyze the correlation between these tools and the occurrence of CRT using AUC, logistic regression, and correlation analyses. The goal is to identify the most accurate and practical screening tool to guide clinical decision-making and minimize chemotherapy toxicity in older adults.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 65 years or older.
- •Histologically confirmed cancer diagnosis with a pre-planned chemotherapy regimen (adjuvant, neoadjuvant, or palliative intent).
- •Chemotherapy not yet initiated at the time of enrollment.
- •Clinically stable condition, as assessed by the oncologist.
- •Willingness and ability to provide written informed consent.
排除标准
- •Presence of acute infection or advanced organ failure (cardiac, hepatic, or renal).
- •Severe psychiatric illness or cognitive impairment that interferes with the ability to complete assessments.
- •Patients receiving concurrent hormonal therapy, targeted therapy, immunotherapy, or radiotherapy.
- •Diagnosis of hematologic malignancies (e.g., leukemia, lymphoma, myeloma).
结局指标
主要结局
Geriartric Form Results and Chemotherapy Side Effects
时间窗: From enrollment to 6 month
ARG (Cancer and Aging Research Group score)
G8 screening tool
时间窗: From enrollment to 6 month
prediction side effets on chemotherapy on patient
Frailty Scale
时间窗: From enrollment to 6 month
Predicting side effect chemoterapy in elderly patient
次要结局
未报告次要终点
研究者
Cemre Aydeğer
Reseach Asistant, Dr.
Çanakkale Onsekiz Mart University