ACTRN12613001383752撤回2 期
A randomised, double-blind, double-dummy study of the effects of insulin and glucagon-like peptide-1 on glycaemia, gastric emptying, gastro-oesophageal reflux and mesenteric blood flow in the critically ill
Dr Yasmine Ali Abdelhamid0 个研究点目标入组 50 人开始时间: 2013年12月17日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 撤回
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •Fifty sedated and mechanically ventilated critically ill patients with stress hyperglycaemia will be recruited from the Intensive Care Unit at the Royal Adelaide Hospital. Stress hyperglycaemia will be defined as a single random blood glucose >10 mmol/L in a patient without a history of formally diagnosed type-1 or type-2 diabetes mellitus who has a glycated haemoglobin (HbA1c) <6.5%. Patients will be between the ages of 18 and 80 years, anticipated to remain ventilated for at least 24 hours and deemed suitable by the treating intensive care physician to receive intragastric enteral nutrition.
排除标准
- •Exclusion criteria will comprise:
- •1. History of type-1 or type-2 diabetes mellitus
- •2. Pregnancy (a BHCG will be performed on all women of child-bearing age)
- •3. Haemoglobin <80g/L
- •4. Contraindication to enteral feeding
- •5. Previous surgery on the oesophagus, stomach or small intestine.
- •6. History of pancreatitis
- •7. Glycated haemoglobin (HbA1c) >/=6.5%
- •8. Prokinetics administered in the preceding 24 hour period
研究者
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