Early Coronary Angiography Associates With Survival Benefit and Longer Time to Initiation of Renal Replacement Therapy in Patients With Advanced Chronic Kidney Disease and Acute Coronary Syndrome: A Survival Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 139
- 主要终点
- Renal replacement therapy initiation
研究概览
简要总结
This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute coronary syndrome.
详细描述
Electronic medical records of adult patients admitted with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital, Thailand, were retrospectively reviewed. Eligible patients should have concurrent advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m² calculated by the 2021 CKD-EPI creatinine equation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m²
- •Diagnosis with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital
排除标准
- •Received maintenance dialysis or kidney transplantation before admission
- •Cardiogenic shock or cardiac arrest
- •Prior PCI or CABG within 12 months
- •Recently diagnosed with ACS within 2 months
- •Had a limited life expectancy due to non-cardiovascular disease
- •Pregnant.
研究组 & 干预措施
Conservative management
Medical management without coronary angiography
Early coronary angiography
Recieve coronary angiography within 24 hours of admission
干预措施: coronary angiography (Procedure)
Delayed coronary angiography
Recieve coronary angiography later than 24 hours of admission
干预措施: coronary angiography (Procedure)
结局指标
主要结局
Renal replacement therapy initiation
时间窗: Until 31 December 2021
Renal replacement therapy initiation
次要结局
- All-cause mortality(Until 31 Dec 2021)
研究者
Thana Thongsricome, MD
Dr.
Chulalongkorn University