Deep squat exercise-exploration of a novel, early self-administered prophylactic tool to delay disability caused by osteoarthritis of knee - a longitudinal study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- biomechanical demands of squat by recording kinetic (forces), kinematic (joint angles), length and activity of muscle (EMG) and neuro-physiological control (postural control). Cellular biochemical response to activity will be assessed by non invasive methods to evaluate anti oxidant activity in body fluids like sweat and urinary cartilage C talopeptide type II collagen.
研究概览
简要总结
The current study aims to define dosimetry of deep squat intervention by comparing three groups of healthy pre OA people (30-50 year old non squatters) based on performance on 30 second deep squat test which reflects on lower limb muscle strength.To demonstrate the effect of deep squat intervention on structural changes in articular cartilage on MRI, biochemical changes on biomarker and disability related variables on biomechanical investigation by implementing the dose specific intervention in people with Grade1-2 OA knee (Kellegren Lawrence grading) with a follow up of one year. Data will be collected and analysed at baseline , 4 week , 8 week. 12 week and 12 months
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 30.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •pre OA people (non squatters-30-50 years) in the age group of 30-50yr will be recruited for the study.
- •People will be screened for inclusion based on X ray findings to confirm pre OA status.
排除标准
- •People engaging in specific sports, recreational physical activity or rehabilitation programs, Females who have undergone menopause , Traumatic, degenerative ,autoimmune ,developmental musculoskeletal or neurological disorders, Cardiovascular and pulmonary disorders , Resting blood pressure >150/90mmHg, Cognitive issues which will prevent comprehension of instructions.
结局指标
主要结局
biomechanical demands of squat by recording kinetic (forces), kinematic (joint angles), length and activity of muscle (EMG) and neuro-physiological control (postural control). Cellular biochemical response to activity will be assessed by non invasive methods to evaluate anti oxidant activity in body fluids like sweat and urinary cartilage C talopeptide type II collagen.
时间窗: baseline, 4 weeks, 8 weeks , 12 weeks, 12 months
次要结局
- participants will undergo prescreening using American College of Sports Medicine ACSM risk factor profile, Physical Activity Readiness Questionnaire (PARQ), Health History Questionnaire (HHQ), International Physical Activity Questionnaire-Short Version (IPAQ), Physiological Stress Scale, Western Ontario Mac Master University Questionnaire (WOMAC )/WOMAC CRD Pune version. Previous squatting exposure will be quantified using MGM Ground Level Activity Exposure questionnaire(MGMGLAE)(baseline, 4 weeks, 8 weeks , 12 weeks, 12 months)