Soothing and Anti-hair Loss Activity of a Scalp Lotion Containing Piroctone Olamine, 2,4 Diaminopyrimidine Oxide and Vichy Mineralizing Water
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- erythema
研究概览
简要总结
Overall, 100 Caucasian subjects participated in this 6-weeks lasting study, AC5+ was applied daily. All subjects had clinically confirmed mild to moderate alopecia and self-declared sensitive scalp. Instrumental assessments included Trans Epidermal Water Loss (TEWL), inflammation markers, clinical assessments included the severity of erythema, inflammation and greasiness. Subjective/Self assessments comprised the intensity of the scalp itch/pruritus and the evaluation of their head hair status (volume, abundance, strength). Same assessments were provided by the investigators.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 接受健康志愿者
- 否
入选标准
- •>18 years
- •mild alopecia:
- •female: Ludwig type 1
- •male: Hamilton III to IV type
排除标准
- •Moderate or severe alopecia
结局指标
主要结局
erythema
时间窗: Day 21
on a scale from o=none to 5=severe
inflammation
时间窗: Day 21
on a scale from o=none to 5=severe
Global soothing score
时间窗: Day 21
sum of the symptoms with a score up to 15
greasiness
时间窗: Day 21
on a scale from o=none to 5=severe
次要结局
- hair quality(Day 21)
- Squalene monohydroperoxide(Day 21)
- pruritus(Day 21)
- burning(Day 21)
- Inflammation markers(Day 21)
- stinging(Day 21)
- scratching(Day 21)
- Transepidermal water loss(Day 21)
- squalene(Day 21)