Analysis of routine data of therapy with intravenous opioid PCA for the relief of dyspnea in palliative care patients
- Conditions
- R06.0Dyspnoea
- Registration Number
- DRKS00004232
- Lead Sponsor
- Interdisziplinäres Zentrum für PalliativmedizinUniversitätsklinikum Düsseldorf
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
Dyspnea >/= NRS 3; inpatients of the University Hospital Dusseldorf, who are treated by the Interdisciplinary Center for Palliative Medicine; indication for PCA therapy in the context of standard treatment of dyspnea; cognitive, physical and verbal skills, that allow the correct handling of a PCA pump
Exclusion Criteria
cognitive, physical and/or linguistic limitation that does not allow the correct handling of an PCA pump; Minimal-Mental State Examination (MMSE) <24 (of 30 max.); allergy, known intolerance or contraindications to morphine and hydromorphone; pregnancy; taking monoamine oxidase inhibitors (MAOI) in the last 2 weeks
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of dyspnea under opioid PCA therapy, on a numeric rating scale from 0 to 10 (NRS 0 = no breathlessness, NRS 10 = maximal imaginable breathlessness) severity is measured before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy
- Secondary Outcome Measures
Name Time Method Changes in physiological parameters measured as respiratory rate, oxygen saturation and Palliative Performance Scale (PPS) before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy; the measuring of satisfaction and acceptance of the therapy using a 6-question questionnaire, 24 and 72 hours after initiation of therapy; description of adverse reactions under PCA opioid therapy before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy; application profile (opioids and their doses, PCA parameters: bolus dose, basal rate, locking time, number and size of boluses given by physicians, number of required and administered boluses by the patient, total dose) before the start of PCA therapy, 5 minutes, 15 minutes, 60-120 minutes, 1 day after initiation of therapy and at each subsequent day of therapy