Intraoperative Use of Lidocaine and Postoperative Analgesia After Laparoscopic Cholecystectomy
Overview
- Phase
- Not Applicable
- Intervention
- Lidocaine
- Conditions
- Postoperative Pain
- Sponsor
- Larissa University Hospital
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- Postoperative opioid consumption
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to evaluate how effective is the intraoperative use of lidocaine to attenuate postoperative pain and opioids consumption after laparoscopic cholecystectomy
Detailed Description
Acute postoperative pain may predict the development of chronic pain.Recently, the analgesic effect of lidocaine, as a part of a multimodal analgesia, has been evaluated in many studies. They have shown that lidocaine may have a role in the postoperative pain management, as an adjunct. Acute postoperative pain after laparoscopic cholecystectomy is complex in nature. Postoperative pain is the main complaint and the primary reason for delay discharge after laparoscopic cholecystectomy.The study includes patients undergoing laparoscopic cholecystectomy.
Investigators
Ioannis Baloyiannis
Assistant Professor of Surgery
Larissa University Hospital
Eligibility Criteria
Inclusion Criteria
- •ASA physical status I-II
- •Age ≥ 18 years old
Exclusion Criteria
- •Allergy in local anesthetics
- •History of liver, kidney or heart failure
- •Existence of chronic pain history or daily analgesics
- •Psychiatric disorders
- •Inability to understand pain assessment
Arms & Interventions
Lidocaine
Intraoperative administration of lidocaine to patients undergo laparoscopic cholecystectomy. Prior induction to anesthesia, lidocaine bolus 1.5 mg / kg will be administered to the lidocaine group and then patients will be connected to a continuous 2 mg / kg / h administration of lidocaine until the end of the procedure.
Intervention: Lidocaine
Placebo
Intraoperative administration of normal saline to patients undergo laparoscopic cholecystectomy.
Intervention: Placebo
Outcomes
Primary Outcomes
Postoperative opioid consumption
Time Frame: 24 hours after the procedure
The total dose of tramadol is calculated as mg and administered intravenously.
Secondary Outcomes
- Change from Baseline Heart Rate(Intraoperative)
- Incidence of shoulder pain(24 hours)
- Change from baseline Mean Blood Pressure(Intraoperative)
- Incidence of sedation and respiratory depression(24 hours)
- Incidence of headache and dizziness(24 hours)
- Change in depth of anesthesia(Intraoperative)
- Incidence of Nausea and Vomiting(24 hours)
- Postoperative pain(24 hrs after the procedure)
- Side effect related to administration of lidocaine(24 hours)