Autofluorescence Detection of Oral Malignancies and Database and Biospecimen Collection to Identify Biomarkers of Head and Neck Tumor Progression

Roswell Park Cancer Institute1 site in 1 country240 target enrollmentMarch 2006

ConditionsOral Cancer

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Oral Cancer
Sponsor: Roswell Park Cancer Institute
Enrollment: 240
Locations: 1
Primary Endpoint: to investigate whether the use of a fluorescent light in the mouth can detect precancers or early cancers that are not seen on normal clinical examination.
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This research may help dentists or surgeons to better detect areas in the mouth that are either prone to cancer or are early cancers. The earlier the detection on cancer in the mouth, the better the chance that treatment or prevention can be more effective.

Registry

clinicaltrials.gov

Start Date

March 2006

End Date

January 2014

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Roswell Park Cancer Institute

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients with a history of suspicious lesions or currant suspicious lesions:
•No history of CIS or HNSCC
•History of clinically suspicious oral/oral pharyngeal lesions.
•Over 21 years old
•Not actively under treatment for any other type of malignancy, except Non-Melanoma Skin Cancer (NMSC)
•Must be willing to sign consent, have AFL screening with biopsies and sample collection, must be willing to complete a social and health history questionnaire
•Patients with biopsy proven dysplasia, CIS or HNSCC prior to treatment:
•Patients with biopsy proven dysplasia, CIS or HNSCC without a prior history of an antineoplastic treatment, including chemo/radiation and Photodynamic Therapy
•Biopsy performed at an outside institution and referred for evaluation for treatment, or biopsied here at RPCI and proceeding for further care.
•Over 21 years of age.

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

to investigate whether the use of a fluorescent light in the mouth can detect precancers or early cancers that are not seen on normal clinical examination.

Time Frame: Once at time of consent (day 1)

The first purpose of this activity is to investigate whether the use of a fluorescent light in the mouth can detect precancers or early cancers that are not seen on normal clinical examination.

Secondary Outcomes

The second purpose is to collect other samples from the mouth in hopes to identify changes in the proteins and/or genes that will help identify how cancers start in the mouth.(Once at time of consent (day 1))