A Comprehensive Prospective Assessment of the Physical and Biological Effects of Upper Tract Urothelial Cancer (UTUC)

Recruiting

• Conditions: Upper Tract Urothelial Cancer

• Registration Number: NCT05438537
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

There are many controversies and limitations in the management of Upper Tract Urothelial cancer. A prospective registry is set up for patients in our hospital, aim to have a comprehensive prospective assessment of the physical and biological effects of Upper Tract Urothelial cancer in our patients

Detailed Description

Although Upper Tract Urothelial Carcinoma (UTUC) is relatively uncommon, the incidence rate is increasing. There are many controversies and limitations in the management of Upper Tract Urothelial cancer.

In this study, investigators would like to establish a local registry for upper tract urothelial cancer to facilitate the collection of clinical information and outcomes of upper tract urothelial cancer management, and to collect blood, urine and tumour tissue samples to investigate for new diagnostic and therapeutic agents. Hopefully, our registry can provide information regarding the epidemiology, natural history, and treatment outcomes of upper tract urothelial cancer in Hong Kong.

Study Timeline

• Study Start: 2021-11-01
• Study First Submitted: 2022-06-24
• Study First Submitted QC: 2022-06-29
• Study First Posted: 2022-06-30
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-21
• Last Update Posted: 2024-01-23
• Primary Completion: 2030-12-30
• Study Completion: 2030-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Male patients > 18 years old
• Patients who has presence of UTUC and pending for surgery
• Patients who has history of UTUC with any intervention performed

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Exclusion Criteria

• Patients fail to provide informed consent

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Long-term survival	10 years	Long-term survival

Secondary Outcome Measures

Name	Time	Method
Progression rate of UTUC	10 years	Progression rate of UTUC
Complications	10 years	Complications are assessed by medical record and on patient follow up
Recurrence rate of UTUC	10 years	Recurrence rate of UTUC

Trial Locations

Locations (1)

Prince of Wales Hospital; 🇭🇰 Hong Kong, Hong Kong