ISRCTN15785949
Active, not recruiting
未知
Risk stratification of interstitial lung abnormalities using hyperpolarised xenon MRI and blood biomarkers
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- The progression of interstitial lung abnormalities into interstitial lung disease
- Sponsor
- Oxford University Hospitals NHS Trust
- Enrollment
- 60
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Participant is willing and able to give informed consent for participation in the study.
- •2\.Male or Female, aged over 18 and under 85 years of age
- •3\.Investigators are of the opinion that the participant is able and willing to comply with the study requirements
- •3\.1\.Lung function tests that are normal or near normal – FVC and TLCO \>70% predicted for age and gender
- •3\.2\.CT imaging fulfils criteria for ILA –
- •3\.2\.1\.Incidental identification of non\-dependent abnormalities on Chest CT, including ground glass or reticular abnormalities, lung distortion, traction bronchiectasis and honeycombing
- •3\.2\.2\.Occupying up to 10% of the lung as agreed independently by two consultant thoracic radiologists
Exclusion Criteria
- •1\.Unable to provide informed consent
- •2\.Contraindication to MRI e.g. shrapnel injury, heavily tattooed, severe claustrophobia
- •3\.Any significant disease or disorder which, in the opinion of the investigator, might influence the interpretation of the clinical data e.g. Significant co\-pathology (e.g. emphysema, poorly controlled asthma, heart failure, pulmonary thromboembolic disease, Covid\-19 condition, pneumotoxic agents resulting in lung damage)
- •4\.Clinical frailty score of 6 or above
- •5\.Female participant who is pregnant, lactating or planning pregnancy.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
Not Applicable
Preoperative risk stratification of lung lesions of unclear dignity by using the EarlyCDT®-Lung test for clinical suspicion of lung carcinomaC34R91Malignant neoplasm of bronchus and lungAbnormal findings on diagnostic imaging of lungDRKS00028546Klinik für Thoraxchirurgie, Krankenhaus Martha-Maria Halle-Dölau250
Completed
Not Applicable
ILAs in CT Lung Cancer Screening PopulationInterstitial Lung DiseaseIPFNCT04503044Lahey Clinic1,703
Recruiting
Not Applicable
Pulmonary involvement (interstitial lung disease of known etiology) in patients with Seropositive and ACPA positive Rheumatoid Arthritis (RA-ILD I and II)Early detection of lung involvement in RAM05.9M05.1J99.0Seropositive rheumatoid arthritis, unspecifiedRheumatoid lung diseaseDRKS00028871Boehringer Ingelheim Pharma GmbH & Co. KG200
Not yet recruiting
Not Applicable
PLHIV-Lung Morbidity Cohort study ( Lung morbidity among people living with HIV)Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecifiedCTRI/2022/06/043487TREAT Asia amfAR The Foundation for AIDS Research through a grant from the US NIH
Completed
Not Applicable
Evaluation of background lung disease as risk factors of the drug-related interstitial pneumonia induced by the lung cancer chemotherapyJPRN-UMIN000026964agasaki University Hospital, Second Department of Internal Medicine214