Effects of deoxycholic acid supplementation on insulin: role for the transmembrane G coupled protein receptor TGR5
Completed
- Conditions
- diabetesobesity10018424
- Registration Number
- NL-OMON45029
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
healthy males 18+
Exclusion Criteria
Major illness in the past 3 months
Gastrointestinal disease that may influence bile acid metabolism
Abnormalities in ASAT / ALAT / Bilirubin / *GT / AF / fasting glucose / HbA1c laboratory data
Drug abuse or alcoholism (>3 units of alcohol per day)
History of cholecystectomy or other bile duct abnormalities.
Strenuous exercise for at least 3 days prior to each study day, defined as more than 1 hour of
exercise per day
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Insulin AUC</p><br>
- Secondary Outcome Measures
Name Time Method <p>Glucose AUC<br /><br>postprandial GLP-1 levels<br /><br>postprandial FGF19 levels</p><br>