Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) effects on perception of illusions, schizotypy and cognition in healthy volunteers

Phase 2

• Conditions: Schizophrenia; Psychosis; Cannabis use safety; Mental Health - Schizophrenia; Mental Health - Psychosis and personality disorders; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12621000469819
• Lead Sponsor: niversity of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-04-21
• Last Update Posted: 26 April 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Inclusion Criteria:
1. They are between 18 and 59 years of age.
2. They are healthy (have no ongoing medical, including psychiatric, condition, other than acne.

Exclusion Criteria

Exclusion Criteria:
1. Any current medical (including psychiatric) condition other than acne.
2. Women that are pregnant or breast-feeding.
3. Women that fertile, sexually active, and not using a contraceptive.
4. Using current prescription medications other than contraceptives or acne medications.
5. A family history of a psychotic illness (E.g., schizophrenia or bipolar disorder) in their first-degree relatives.
6. Use of any drugs other than contraceptives or acne medications 48 hours before the testing days. These include prescription medications, over-the-counter medications or naturopathy” medications such as St John’s Wort (that can interfere with drug metabolism), but do not include nicotine if the person is nicotine-dependent as withdrawal from nicotine produces an unusual physiological state.
7. History of a major brain or head injury.
8. Need for a hearing aid.
9. Poor eyesight when wearing glasses.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Experience of the rubber hand illusion with varying temporal and spatial interstimulus intervals assessed as the change in a self-report subjective experience scale (scores after the illusion - scores before the illusion) [These will be measured on all days of testing (placebo and drug days). The rubber hand illusion is measured ~255 min after the second capsule. This is the last test of the day for each day. ]