A Phase 1/2 Study Evaluating the Safety, Pharmacokinetics and Efficacy of Venetoclax in Japanese Subjects With Hematological Malignancies
Overview
- Phase
- Phase 1
- Intervention
- venetoclax
- Conditions
- Non-Hodgkin Lymphoma (NHL)
- Sponsor
- AbbVie
- Enrollment
- 38
- Locations
- 14
- Primary Endpoint
- Time to maximum plasma concentration (Tmax) of venetoclax
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study is evaluating the safety, pharmacokinetic profile and efficacy of venetoclax under a once daily dosing schedule in Japanese participants with hematological malignancies.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participants must have histologically documented diagnosis of NHL (and exhausted options considered standard of care) as defined in the World Health Organization classification scheme and relapsed following or be refractory to standard treatments such as R-CHOP, R-CVP, or fludarabine based regimens. Participants with other lymphoproliferative diseases can be considered in consultation with the AbbVie medical monitor
- •Relapsed or refractory multiple myeloma participants must have been previously treated with at least one prior line of therapy and have measurable disease
- •Chronic lymphocytic leukemia/small lymphocytic lymphoma participants must have relapsed or be refractory to standard treatments such as fludarabine based regimens or alkylator based regimens
- •Untreated AML subjects or Relapsed or refractory AML subjects must have been previously treated with at least one prior line of therapy
- •Eastern Cooperative Oncology Group (ECOG) performance score less than or equal to 1; adequate bone marrow independent of growth factor support per local laboratory reference range; and adequate coagulation, renal, and hepatic function, per laboratory reference range at Screening
- •Participants with a history of autologous or allogenic stem cell transplantation must have adequate blood counts independent of growth factor support and have recovered from any transplant-related toxicity(s) and be at least 100 days post-autologous transplant (multiple myeloma) or 6 month post-autologous transplant (NHL) prior to first dose of study drug or at least 6 months post-allogenic transplant (multiple myeloma) prior to first dose of study drug and not have active graft-versus-host disease (GVHD), i.e., requiring treatment
Exclusion Criteria
- •NHL participants who have undergone an allogeneic stem cell transplant or were diagnosed with Post-Transplant Lymphoproliferative Disease, Burkitt's lymphoma, Burkitt-like lymphoma, or lymphoblastic lymphoma/leukemia
- •Participant tested positive for HIV
- •Participant has a cardiovascular disability status of New York Heart Association Class greater or equal to 2
- •Participant has a significant history of renal, neurologic, psychiatric, pulmonary, endocrinologic, metabolic, immunologic, cardiovascular, or hepatic disease that in the opinion of the Investigator would adversely affect his/her participating in this study.
- •Participant received a monoclonal antibody for anti-neoplastic intent within 8 weeks prior to the first dose of study drug.
Arms & Interventions
Arm A (Phase 1)
Step-up doses of venetoclax to the designated cohort dose administered in participants with relapsed or refractory (R/R) Non-Hodgkin lymphoma (NHL) or multiple myeloma (MM)
Intervention: venetoclax
Arm B (Phase 1)
Step-up doses of venetoclax to the designated dose administered in participants with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
Intervention: venetoclax
Arm C (Phase 1)
Step-up doses of venetoclax to the designated dose with the addition of azacitidine administered in participants with acute myeloid leukemia (AML)
Intervention: azacitadine
Arm C (Phase 1)
Step-up doses of venetoclax to the designated dose with the addition of azacitidine administered in participants with acute myeloid leukemia (AML)
Intervention: venetoclax
Arm D (Phase 2)
Step-up doses of venetoclax to the designated dose with the addition of rituximab in participants with R/R CLL
Intervention: venetoclax
Arm D (Phase 2)
Step-up doses of venetoclax to the designated dose with the addition of rituximab in participants with R/R CLL
Intervention: rituximab / IDEC-C2B8
Outcomes
Primary Outcomes
Time to maximum plasma concentration (Tmax) of venetoclax
Time Frame: Approximately 8 days
Number of participants having treatment-emergent adverse events
Time Frame: Approximately 2 years
Collect all adverse events at each visit
Maximum plasma concentration (Cmax) of venetoclax
Time Frame: Approximately 8 days
Area under the plasma concentration-time curve from 0 to 24 hours (AUC24) post-dose of venetoclax
Time Frame: Approximately 8 days
Objective Response Rate (Phase 2)
Time Frame: Approximately 48 months
The proportion of participants with response (e.g., partial, complete response) using IWCLL (International Workshop on Chronic Lymphocytic Leukemia) criteria for CLL participants will be computed for all participants with active disease at baseline (in the opinion of the investigator).
Secondary Outcomes
- Objective Response Rate (Phase 1)(Approximately 48 months)
- Minimal Residual Disease (MRD)(Approximately 2 years)
- Duration of Response(Approximately 48 months)
- Time to disease progression(Approximately 48 months)
- complete response or remission (CR) rate(Approximately 48 months)
- Partial response or remission (PR) rate(Approximately 48 months)
- Progression Free Survival (PFS)(Approximately 48 months)