Determining the Reproductive Health of Men Post-COVID-19 Infection
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Semen parameters
研究概览
简要总结
Study rationale
- An increasing proportion of the worldwide population is being infected with COVID-19.
- There are ongoing and currently unanswered safety concerns about the effects of COVID-19 on reproductive health.
- It will be immensely reassuring to rapidly report that COVID-19 has no detectable effects on male endocrine or sperm function. Conversely, if COVID-19 does impair male reproductive health, appropriate screening can be performed in couples trying to conceive, and further research can be undertaken.
- The proposed study will be simple, rapid, and authoritative for the UK and worldwide.
详细描述
Male infertility results from impaired sperm function, and account for half of all infertility. Fertility services have been reported to cost £325M annually in the UK(4) (REF). Testosterone deficiency is one of the most common hormonal problems affecting men, leading to osteoporosis, type 2 diabetes, obesity and depression(5).
Concerns have been raised about the potential effects of COVID-19 on male reproductive dysfunction (male infertility and testosterone deficiency). A recent study has suggested that COVID-19 may enter human cells by binding to receptors (special gates on cells that recognise a specific molecule) for angiotensin converting enzyme 2 (ACE2)(6) . ACE2 receptors are found at very high levels in the testes. Within the testes, ACE2 is found on developing sperm, the 'nurse cells' that help the sperm grow (Sertoli cells), and also on Leydig cells which are needed to make the male sex hormone testosterone. In summary, this evidence suggests that there is a plausible link why COVID-19 would cause male infertility and testosterone deficiency.
All fertility treatment in the UK is regulated by the Human Fertility and Embryology Authority (HFEA). The HFEA has prohibited on all non-cancer fertility treatment in the UK between April 15th and May 12th 2020 due to the COVID-19 epidemic. It is important to rapidly screen and report whether COVID-19 has any obvious effects in causing male infertility and testosterone deficiency. It must be noted that a recent study(1) reported that COVID-19 is not spread by human semen and therefore, semen processing should not risk staff to COVID-19 infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Men 18-50 years of age
- •Already attending hospital for another reason
- •Low risk of prior COVID-19 infection(EITHER Negative positive COVID-19 PCR test result within last 4 weeks OR no history suggestive of COVID-19 illness)
- •High risk of prior COVID-19 infection(EITHER Prior positive COVID-19 PCR test result OR history suggestive of COVID-19 illness)
排除标准
- •Men with current symptoms of COVID-19 infection
- •Men currently self-isolating as per UK government advice for COVID-19 infection
- •Needle-phobia
- •Impaired ability to provide full consent to take part in the study
- •History of co-morbidity likely to affect male reproductive function e.g. undescended testes, removal of testes, testicular cancer, drugs such as corticosteroids or testosterone therapy.
结局指标
主要结局
Semen parameters
时间窗: 3 visits (up to 75 days apart)
Sperm concentration (x10\^6/ml) between case and control group.
Sperm Parameters
时间窗: 3 visits (up to 75 days apart)
Sperm normal morphology (%) between case and control group.
Hormones measurement
时间窗: 3 visits (up to 75 days apart)
Luteinising hormone(IU/L) between case and control group.
次要结局
- Seminal Reactive oxygen species(3 visits (up to 75 days apart))
- Sperm DNA fragmentation rate(3 visits (up to 75 days apart))