NCT00193115已完成2 期
Phase II Pilot Trial of Dose-Dense Docetaxel Followed by Doxorubicin Plus Cyclophosphamide (T-AC) Given as Adjuvant or Neoadjuvant Treatment for Women With Node Positive or High-Risk Primary Breast Cancer
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 32
- 主要终点
- Treatment-related toxicities
研究概览
简要总结
This protocol will evaluate the feasibility and toxicity of dose-dense docetaxel followed by doxorubicin and cyclophosphamide with support given as adjuvant or neoadjuvant treatment of women with node positive and high risk breast cancer
详细描述
Upon determination of eligibility, patients will receive:
Neoadjuvant Docetaxel + Doxorubicin + Cyclophosphamide + Surgery
Adjuvant patients will enter the study after surgery and receive Docetaxel+ Doxorubicin + Cyclophosphamide. Patients treated with lumpectomy will undergo postoperative radiation therapy after completion of chemotherapy. Patients with positive estrogen and/or progesterone receptors will begin anti-estrogen therapy after the last course of chemotherapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •To be included in this study, you must meet the following criteria:
- •Histologically proven breast cancer
- •Females, age greater than 18 years
- •Ability to perform activites of daily living with minimal assistance
- •Normal cardiac function
- •Adequate bone marrow, liver and kidney
- •Signed informed consent prior to beginning specific protocol procedures
排除标准
- •You cannot participate in this study if any of the following apply to you:
- •Prior systemic anticancer therapy for breast cancer
- •Prior anthracycline or taxane based chemotherapy for any malignancy
- •Pregnant or breast-feeding women.
- •Pre-existing moderate to severe motor or sensory neurotoxicity
- •Other serious illness or medical condition
- •Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have.
结局指标
主要结局
Treatment-related toxicities
次要结局
- Overall response rate
- Overall survival
研究者
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