The effect of fasting duration on the circulating blood volume

Not Applicable

• Conditions: Patients undergoing elective surgery under general anesthesia

• Registration Number: JPRN-UMIN000005696
• Lead Sponsor: Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences

Brief Summary

We hypothesized that the preoperative volume deficit associated with a 2 h oral intake restriction is smaller than that associated with a 4 h restriction. We tested this hypothesis using the SVV following anesthetic induction. The primary outcome was the difference between the two groups in the volume required to achieve recovery to an SVV value of < 13% With respect to the primary outcome, a greater amount of infusion was required in the 4 h restriction group (2.2 ml/kg) than in the 2 h restriction group (1.7 ml/kg), without statistical significance (P = 0.378). Our study demonstrated that the preoperative volume deficit after a 2 h liquid intake restriction is comparable to that after a 4 h restriction.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-06
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

Not provided

Exclusion Criteria

ASA physical status >=3, Obesity (BMI>30), Height>=185cm, Weight>=80Kg, Age>70 and <20

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the stroke volume variation of 2-hour fast with that of 4-hour fast to confirm the effect of fast duration on the circulating blood volume

Secondary Outcome Measures

Name	Time	Method
To assess the quantitative fluid deficits for optimal circulating blood volume