Predictive Factors for Initial MMSE Score and Rapid Decline in Alzheimer's Disease Patients

Not yet recruiting

• Conditions: Alzheimer Disease; Mini-Mental State Examination; Cognitive Dysfunction; Neuropsychological Tests; Caregivers

• Registration Number: NCT07122856
• Lead Sponsor: Centre Hospitalier de Gonesse

Brief Summary

This study looks at people with Alzheimer's disease to find out which factors are linked to their initial score on the Mini-Mental State Examination (MMSE) and which factors may predict a fast decline in their score over 12 months. Researchers will review medical records from patients seen at the Memory Clinic of Gonesse Hospital and analyze information such as age, education, medical history, nutrition, mood, and caregiver burden. The goal is to better understand what influences early cognitive performance and how quickly it changes, to help improve patient care and planning.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-08
• Study First Submitted: 2025-08-08
• Study First Submitted QC: 2025-08-08
• Last Update Submitted: 2025-08-08
• Study First Posted: 2025-08-14
• Last Update Posted: 2025-08-14
• Study Start: 2025-09-15
• Primary Completion: 2026-03-15
• Study Completion: 2026-03-15

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Confirmed diagnosis of Alzheimer's disease according to NIAA 2018 or IWG 2021 criteria
• At least two MMSE evaluations spaced 12 months apart
• Follow-up at the Memory Clinic of CH Gonesse

Exclusion Criteria

• Presence of other neurodegenerative diseases (e.g., Frontotemporal Dementia, Multiple System Atrophy, Vascular Dementia, LATE)
• Patient has moved out of the study area (outside the CH Gonesse territory)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in MMSE Score Over 12 Months - measured as either a decrease of ≥3 points on the Mini-Mental State Examination [MeSH] or patient institutionalization within 12 months.	12 months

Trial Locations

Locations (1)

Centre Hospitalier de Gonesse; 🇫🇷 Gonesse, France