Identification of Gut Microbiota Signatures Associated With Health Metrics in a Community-based Adult Cohort: a Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,530
- 试验地点
- 1
- 主要终点
- Identification of Health-Relevant Signatures in Adults
研究概览
简要总结
Mining the gut microbiota of adults for health-relevant microbial signatures.
详细描述
This study is a community-based, observational cross-sectional investigation, enrolling 1,530 middle-aged and elderly volunteers.
Data were collected through a systematic, multi-dimensional assessment, which included:
Biospecimen Collection: Blood, urine, and stool samples were obtained from the volunteers.
Physical and Imaging Examinations: Procedures included anthropometric measurements, vital sign monitoring, oral examinations, electrocardiograms, physical examinations of key organs, and abdominal ultrasonography.
Psychological and Cognitive Assessments: Standardized scales were administered to assess anxiety/depression and memory function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Community-dwelling adults aged 30 to 95 years.
- •Individuals who underwent an annual health examination at the Health Management Center of Huzhou Central Hospital during the specified time period.
- •Ability to comprehend the study content and voluntarily provide signed informed consent.
- •Willingness and ability to provide the required biospecimens (blood, urine, stool).
排除标准
- •Concurrent participation in another interventional clinical trial that is likely to interfere with the results of this study.
- •Voluntary withdrawal from the study.
结局指标
主要结局
Identification of Health-Relevant Signatures in Adults
时间窗: Baseline
Primary Outcome Measure 1)Change in standard laboratory parameters from baseline:Changes in routine laboratory parameters measured in blood, urine, and stool samples, including complete blood count and standard serum biochemistry panels.Unit of Measure: Various laboratory units (e.g., g/L, U/L, mmol/L); 2) Change in anthropometric measurements from baseline: Anthropometric measurements including body weight (kg), height (m), and body mass index (BMI, kg/m²).Unit of Measure:kg, m, kg/m²; 3) Alcohol consumption status: Alcohol consumption status assessed by self- report, categorized as current drinker or non-drinker at enrollment.Unit of Measure:Categorical (yes/no); 4) Hospital Anxiety and Depression Scale (HADS) scores: Anxiety and depression symptom severity assessed using the Hospital Anxiety and Depression Scale, including anxiety and depression subscale scores.Unit of Measure:Score on a standardized scale.
次要结局
未报告次要终点
研究者
Xiaolong He
Department of Laboratory Medicine
Zhujiang Hospital