Memory During Inhalation Anesthesia Performed With or Without Bispectral Index (BIS) in Patients Undergoing Thyroidectomy
试验速览
- 阶段
- 不适用
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Implicit memory
研究概览
简要总结
The purpose of this study is 1) to investigate whether the use of BIS as a guide to the administration of inhaled anesthetic (sevoflurane or desflurane) compared with the use of hemodynamic parameters (blood pressure and heart rate) would affect the occurrence of implicit memory and /or dreams recall and 2) to check whether the occurrence of implicit memory and/or dreams recall is related with MAC (Minimal Alveolar Concentration) of inhalational anesthetics and/or preoperative anxiety levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 70 years
- •Class-ASA Physical Status I-II
排除标准
- •Psychiatric or neurological disorders and/or hearing disorders
- •Obesity (Body Mass Index > 30)
- •Drug addiction, alcoholism
- •Patient with difficulty in understanding italian language and/or education level below middle school
研究组 & 干预措施
Hemodynamic parameters
Hemodynamic parameters will be used as a guide for anesthesia.
干预措施: Inhaled anesthetics (Drug)
BIS
Bispectral Index (BIS) will be used as a guide for anesthesia.
干预措施: Inhaled anesthetics (Drug)
结局指标
主要结局
Implicit memory
时间窗: Approximately 24 hours after surgery
Implicit memory will be investigated using free association test: patients, during maintenance of anesthesia, will listen a piece of one of two stories, "Puss in Boots" or "Pinocchio", each followed by four keywords. Approximately 24 hours after surgery, patients will be asked to associate the first thing that comes to mind with these keywords in order to highlight the presence of implicit memory. The test will be repeated twice and will be positive if the patient will reply with the title of the story or a word of it.
次要结局
- Dreams recall(Approximately 24 hours after anaesthesia)
- Explicit memory(Approximately 24 hours after surgery)