Hyperpolarized 129Xe MRI Lung Health Cohort
Recruiting
- Conditions
- Healthy
- Registration Number
- NCT05766384
- Lead Sponsor
- University of Kansas Medical Center
- Brief Summary
A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 260
Inclusion Criteria
- Is enrolled in the American Lung Association Lung Health Cohort Study.
- Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date.
Exclusion Criteria
- Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, > 140 cm shoulder circumference, dependent on weight distribution).
- Is pregnant or breastfeeding
- Oxygen saturation (SpO2) <88% on room air or with supplemental oxygen.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Xe-MRI Apparent Diffusion Coefficient At baseline imaging timepoint Correlation of Xe-MRI with FEV1/FVC and other measures of lung function
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (6)
University of Illinois-Chicago
🇺🇸Chicago, Illinois, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States
Duke University
🇺🇸Durham, North Carolina, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States