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Clinical Trials/NCT07188116
NCT07188116Not yet recruitingNot Applicable

Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer: A Historical Cohort Study

Zhejiang Hospital1 site in 1 country200 target enrollmentStarted: September 15, 2025Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
200
Locations
1
Primary Endpoint
Radiation Pneumonitis Situation

Study Overview

Brief Summary

This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients.

Detailed Description

This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients. Breast cancer patients who underwent radiotherapy at the Cancer Center of Zhejiang Hospital between January 1, 2021, and June 30, 2024, were screened for eligibility. Patients who met the inclusion criteria were identified through the hospital information system, and their clinical records were reviewed. Follow-up was conducted via telephone interviews.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to 80 Years (Adult, Older Adult)
Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • patients with pathologically or cytologically confirmed primary breast cancer,
  • aged 18 years or older but younger than 80 years,
  • with complete and reliable medical records,
  • for those with COVID-19 infection, documented evidence of a positive test result.

Exclusion Criteria

  • concomitant pulmonary malignancies,
  • a history of prior thoracic radiotherapy,
  • concurrent pulmonary infections other than COVID-19 during radiotherapy,
  • missing key data with loss to follow-up,
  • or any other condition considered unsuitable for enrollment by the investigators.

Outcomes

Primary Outcomes

Radiation Pneumonitis Situation

Time Frame: From January 2021 to June 2024

The incidence rate, severity and onset time of radiation pneumonitis

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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