Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer: A Historical Cohort Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Zhejiang Hospital
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Radiation Pneumonitis Situation
Study Overview
Brief Summary
This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients.
Detailed Description
This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients. Breast cancer patients who underwent radiotherapy at the Cancer Center of Zhejiang Hospital between January 1, 2021, and June 30, 2024, were screened for eligibility. Patients who met the inclusion criteria were identified through the hospital information system, and their clinical records were reviewed. Follow-up was conducted via telephone interviews.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients with pathologically or cytologically confirmed primary breast cancer,
- •aged 18 years or older but younger than 80 years,
- •with complete and reliable medical records,
- •for those with COVID-19 infection, documented evidence of a positive test result.
Exclusion Criteria
- •concomitant pulmonary malignancies,
- •a history of prior thoracic radiotherapy,
- •concurrent pulmonary infections other than COVID-19 during radiotherapy,
- •missing key data with loss to follow-up,
- •or any other condition considered unsuitable for enrollment by the investigators.
Outcomes
Primary Outcomes
Radiation Pneumonitis Situation
Time Frame: From January 2021 to June 2024
The incidence rate, severity and onset time of radiation pneumonitis
Secondary Outcomes
No secondary outcomes reported