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临床试验/CTRI/2025/08/093731
CTRI/2025/08/093731尚未招募2 期

Effect of Resistance Training and Modified Protein Intake on Muscle Mass In PRE-SARCOPENIC Individuals

Nopany Institute of Healthcare Studies1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2026年8月4日最近更新:

试验速览

阶段
2 期
状态
尚未招募
发起方
入组人数
30
试验地点
1
主要终点
Muscle Mass

研究概览

简要总结

Sarcopenia, a progressive age-related condition marked by the decline of muscle mass, strength, and function, often begins after the age of 50. While resistance training is known to effectively increase muscle mass (CC), insufficient protein intake may accelerate the onset. This study aimed to evaluate the combined and individual effects of resistance training and modified plant-based protein intake on muscle mass in individuals with pre-sarcopenia. A total of 40 participants were initially recruited through convenience sampling, with 12 dropping out, leaving 28 individuals divided into two groups. Group A (n=15) engaged in elastic band resistance training along with a prescribed plant-based protein diet, while Group B (n=13) performed the same exercise regimen without dietary modification. Both groups trained for 45 minutes, three times a week, over 10 weeks. Post-intervention analysis revealed significant improvements in CC, SMM and QOL within both groups (p<0.05). However, no significant differences were found between the two groups. The study concludes that Resistance Training and the modified protein group showed greater improvements in mean values as compared to Resistance Training alone; however, neither group outperformed the other.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Participant Blinded

入排标准

年龄范围
50.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • Calf circumference: less than 34 cm for males, less than 33 cm for females Body Mass Index: less than 24kg/m2.

排除标准

  • Non-ambulatory Non-cooperative patients Protein allergy Cognitive impairments Neurological disorders (like stroke, Alzheimer’s disease, etc.) • Cardiovascular diseases or uncontrolled hypertension • Previous surgery on lower limbs affecting gait • Severe arthritis • Persons with fever or any kind of systemic infection.

结局指标

主要结局

Muscle Mass

时间窗: 10 weeks

Skeletal Muscle Mass

时间窗: 10 weeks

次要结局

  • Quality of life assessed by Sarqol questionnaire(10 weeks)

研究者

发起方
Nopany Institute of Healthcare Studies
申办方类型
Private hospital/clinic
责任方
Principal Investigator
主要研究者

Snehasish Laha

Nopany Institute of Healthcare Studies

研究点 (1)

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