Sleep quality in critically ill patients on proportional assist ventilation with load-adjustable gain factors (PAV+) vs pressure support (PS)

Completed

Conditions: Sleep quality in critically ill patients on mechanical ventilation
Respiratory

Registration Number: ISRCTN80274260

Lead Sponsor: Cretan Critical Care Society (Greece)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 10

Inclusion Criteria

Critically ill patients (>18 years old, both males and females) who are receiving mechanical ventilation for at least 48 hours will be studied. At the time of the study all patients will be haemodynamically stable and ventilated on PS through cuffed endotracheal or tracheostomy tubes with anticipated further mechanical ventilation of at least 24-h duration. All patients must achieve a score of 0 on the Richmond Agitation Sedation Scale (RASS) either with or without intravenous (IV) propofol.

Exclusion Criteria

1. Anticipated ICU stay <24 h
2. Premorbid diseases that could confuse interpretation of sleep monitoring including central nervous system (CNS) diseases and sleep disorders
3. Haemodynamic instability (BP <90 mmHg despite therapy)
4. Glasgow Coma Scale <11 and acute physiology score >13
5. General anesthetic, drug overdose, or alcohol intoxication within the preceding 24 h

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of PAV and PS in sleep quality.

Secondary Outcome Measures

Name	Time	Method
Patient - ventilator interaction during sleep. Flow (V?), volume (V), airway pressure (Paw), end-tidal CO2 (PETCO2), the motion of the rib cage and abdomen, inspiratory (TI) and expiratory (TE) time, total respiratory cycle time (TTOT) and peak inspiratory airway pressure (Pawpeak) will be measured on a breath-by breath basis, while coefficient of variation of tidal volume (VT) and TTOT will be calculated.