CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight
- Conditions
- Healthy
- Registration Number
- NCT02611947
- Lead Sponsor
- Erasme University Hospital
- Brief Summary
Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.
- Detailed Description
87 healthy volunteers performed consecutively a low-dose chest CT scan and pulmonary function tests:
1. On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions.
Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded.
2. Pulmonary function tests were performed: vital capacity, forced vital capacity , functional residual capacity, total lung capacity, residual volume, forced expiratory volume in one second, and diffusion lung capacity for carbon monoxide were recorded (either in absolute values and percentage of predicted values).
CT indexes were compared with gender, height and weight.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 87
- Never smoked.
- No respiratory infection in the 4 weeks before the begin of the study.
- No history of pulmonary resection.
- No active malignancy or malignancy of any organ system within the past 5 years.
- no exclusion criteria
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CT index - RA960 (%) 4 hours From acquired data, images were reconstructed using a soft algorithm. On these soft images, the relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units was computed (expressed in %), as an index representative of pulmonary emphysema extent.
CT index - LA4th (mm2) 4 hours From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in fourth generations of airways (expressed in mm2).
CT index - LA3rd (mm2) 4 hours From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in third generations of airways (expressed in mm2).
CT index - WT4th (mm) 4 hours From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in fourth generations of airways (expressed in mm).
CT index - WT3rd (mm) 4 hours From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in third generations of airways (expressed in mm).
- Secondary Outcome Measures
Name Time Method Pulmonary function tests - TLC (l) 4 hours Total lung capacity was measured (expressed in l).
Pulmonary function tests - DLCO (ml/min/ mmHg) 4 hours Diffusion lung capacity for carbon monoxide was measured (expressed in ml/min/ mmHg)
Pulmonary function tests - VC (l) 4 hours Vital capacity was measured (expressed in l).
Pulmonary function tests - FRC (l) 4 hours Functional residual capacity capacity was measured (expressed in l).
Pulmonary function tests - RV (l) 4 hours Residual volume was measured (expressed in l).
Pulmonary function tests - FVC (l) 4 hours Forced vital capacity was measured (expressed in l).
Pulmonary function tests - FEV1 (l) 4 hours Forced expiratory volume in one second was measured (expressed in l).
Trial Locations
- Locations (1)
Erasme University Hospital
🇧🇪Brussels, Belgium
Erasme University Hospital🇧🇪Brussels, Belgium