A Comparative Study Between Levobupivacaine 0.5% and Ropivacaine 0.75% in Patients Undergoing Spinal Anaesthesia for Lower Limb Orthopaedic Surgery.
Overview
- Phase
- Phase 4
- Intervention
- Levobupivacaine
- Conditions
- Lower Limb Surgery
- Sponsor
- Aligarh Muslim University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Duration of Analgesia
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of this study is to compare the effects of two intrathecally administered drugs:0.5% levobupivacaine and0.75%Ropivacaine in spinal anesthesia
Detailed Description
Bupivacaine is a highly cardiotoxic drug and also produces prolonged motor blockade.The newer drugs levobupivacaine and ropivacaine being comparatively less cardio and neurotoxic are preferred now a days.So, we conducted this prospective, randomized double blind study with an aim of comparing the efficacy and characteristics of these drugs.
Investigators
MANAZIR ATHAR
Doctor
Aligarh Muslim University
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists (ASA) class I \& II patients of either sex
- •Age between 18-60 years
Exclusion Criteria
- •Patient's refusal.
- •Patients who have contraindications to spinal anaesthesia / Local anaesthetic drugs.
- •Patients having h/o diabetes, neurological and musculoskeletal diseases.
Arms & Interventions
Levobupivacaine 0.5%
intrathecal administration of 15 mg of Levobupivacaine 0.5%
Intervention: Levobupivacaine
Ropivacaine 0.75%
intrathecal administration of 22.5 mg of Ropivacaine 0.75%
Intervention: Ropivacaine
Outcomes
Primary Outcomes
Duration of Analgesia
Time Frame: 8 hours
Defined as time for first analgesic request by the patient
Secondary Outcomes
- Duration of Motor Block(8 hours)
- Onset of Sensory Block at T10(30 minutes)
- Median Maximum Level of Sensory Blockade(8 hours)
- Time to Maximum Cephalic Spread of Sensory Block(8 hours)
- Onset of Motor Block to Bromage3(8 hours)