High (greater than 0.40) versus Low (greater than 0.30) Fractional Inspired Oxygen Threshold for Surfactant Therapy in Preterm Infants with Respiratory Distress Syndrome- A Randomized Controlled Trial.

preterm were major contributing for nicu admission ,in which major morbidity being respiartory disress syndrome,cornerstone mangement for respiratory distress syndrome is respiartory support(cpap/mechanical ventilator) and surfactant repalcement.we came long way from routine intubation and prophylatic surfactant admisnatration coupled with ongoing invasive mechanical ventilation,to the present day predominant approach of management mainly use of non inavsive support(cpap) and selctive surfactant admsinatration.most common parameter used is FIO2 thershold ,regrading thershold differnent bodies uses differnet fio2 thershold,we use fio2 thershold 30% (eurpoean guidelines 2022).but at this thershold there is possiblity of overuse of surfactant ,so this study was planned to bring optimal fio2 thershold for surfactant administration for babies stabilized on cpap.Aim of the study is to comapre the need for mechanical vetlation admistrating surfactant at high(0.40) versues low(0.30) fio2 thershold in preterm infants with respiratory distress syndrome ,with primary objective to compare the need for mechanical ventilation in the first 72hrs.