Tranexamic Acid : Nebulization vs IV Route for Hemoptysis
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Enrollment
- 172
- Locations
- 1
- Primary Endpoint
- Time to control hemoptysis
Study Overview
Brief Summary
This study compares the effect of tranexamic acid on hemoptysis when given through the conventional IV route and Through nebulization.
Detailed Description
The investigators are conducting a randomized controlled trial for the comparison of routes through which tranexamic acid can be given to control hemoptysis. The study participants will be divided into 2 groups randomly and 1 group will be assigned to use IV route while other will be assigned the nebulization route and the result variables include the time taken for complete control of hemoptysis and recurrence time. Another variable is the reduction in amout of blood in sputum after each intervention.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Masking Description
There is no masking as the participnats will be explained the whole process and consent would be taken for using the either route for administration of tranexamic acid
Eligibility Criteria
- Ages
- 12 Years to 80 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with mild to moderate hemoptysis < 600ml/ 24 hours of age 12 to 80 years and both genders.
- •Patients with hemoptysis due to infective pathology.
- •Patients with hemoptysis due to malignant pathology.
Exclusion Criteria
- •Patients on antiplatelet therapy or aspirin
- •Hemoptysis after penetrating lung injury e.g. firearm injury
- •Patients with history of asthma
Arms & Interventions
Group receiving tranexamic acid via IV route
Tranexamic acid has been used conventionally for hemoptysis via IV route
Intervention: Tranexamic Acid (TXA) (Drug)
The Group receiving tranexamic acid via nebulization
Tranexamic acid when given through nebulization can be more effective than IV route in controlling hemoptysis
Intervention: Tranexamic Acid (TXA) (Drug)
Outcomes
Primary Outcomes
Time to control hemoptysis
Time Frame: 48 hours
In this study the time taken by tranexamic acid to acehive comolete control of hemoptysis will be compared when given through IV and nebulization.
Secondary Outcomes
No secondary outcomes reported
Investigators
Laiba Qamar
Principal Investigator
University of Health Sciences Lahore