Tranexamic Acid : Nebulization vs IV Route for Hemoptysis

Not Applicable

Recruiting

• Conditions: Hemoptysis; NEBULIZATION; Tranexamic Acid
• Interventions: Drug: Tranexamic Acid (TXA)

• Registration Number: NCT07212452
• Lead Sponsor: University of Health Sciences Lahore

Brief Summary

This study compares the effect of tranexamic acid on hemoptysis when guven through the conventional IV route and Through nebulization.

Detailed Description

We are conducting a randomized controlled trial for the comparison of routes through which tranexamic acid can be given to control hemoptysis. The study participants will be divided into 2 groups randomly and 1 group will be assigned to use IV route while other will be assigned the nebulization route and the result variables include the time taken for complete control of hemoptysis and recurrence time. Another variable is also the reduction in amout of blood in sputum after each intervention.

Study Timeline

• Study Start: 2025-08-01
• Status Verified: 2025-09
• Study First Submitted: 2025-09-30
• Study First Submitted QC: 2025-09-30
• Last Update Submitted: 2025-09-30
• Study First Posted: 2025-10-08
• Last Update Posted: 2025-10-08
• Primary Completion: 2025-10-31
• Study Completion: 2025-11-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 172

Inclusion Criteria

1. Patients with mild to moderate hemoptysis < 600ml/ 24 hours of age 12 to 80 years and both genders.
2. Patients with hemoptysis due to infective pathology.
3. Patients with hemoptysis due to malignant pathology.

Exclusion Criteria

1. Patients on antiplatelet therapy or aspirin
2. Hemoptysis after penetrating lung injury e.g. firearm injury
3. Patients with history of asthma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group receiving tranexamic acid via IV route	Tranexamic Acid (TXA)	Tranrxamic acid has been used conventionally for hemoptysis via IV route
The Group receiving tranexamic acid via nebulization	Tranexamic Acid (TXA)	Tranexamic acid when given through nebulization can be more effective than IV route in controlling hemoptysis

Primary Outcome Measures

Name	Time	Method
Time to control hemoptysis	48 hours	In this study the time taken by tranexamic acid to acehive comolete control of hemoptysis will be compared when given through IV and nebulization.

Trial Locations

Locations (1)

Services Hospital Lahore; 🇵🇰 Lahore, Punjab Province, Pakistan