Intracardiac T-wave Alternans and Ischemia During Percutaneous Coronary Interventions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ischemia
- Sponsor
- Columbia University
- Enrollment
- 11
- Locations
- 1
- Primary Endpoint
- Number of Subjects With Positive T Wave Studies During a Coronary Intervention
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
T-wave alternans is a test that looks at microvolt changes in the T-wave on a beat to beat basis. The presence or absence of such changes has been shown to predict or exclude future arrhythmic events. The mechanism of T-wave alternans is unclear, but may relate to calcium metabolism in the heart, and may be affected by conditions such as ischemia or heart failure.
The purpose of this study is to determine whether T-wave alternans, as measured through the lead of an implantable defibrillator, is produced by acute ischemia induced by occlusion during percutaneous coronary interventions.
Investigators
Jose M. Dizon
Assoc Professor of Clinical, Department of Medicine Cardiology
Columbia University
Eligibility Criteria
Inclusion Criteria
- •patient with CAD undergoing PCI with appropriate Medtronic implantable defibrillator.
Exclusion Criteria
- •non-elective procedure
- •non-qualifying defibrillator type.
Outcomes
Primary Outcomes
Number of Subjects With Positive T Wave Studies During a Coronary Intervention
Time Frame: During the coronary intervention, upto 2 hours
Positive T wave alternans is determined by a proprietary program using ECG recordings during a stress test. The result is reported as positive, negative, or indeterminate.