Efficiency of 7.2% hypertonic saline hydroxyethyl starch 200/0.5 versus mannitol 15% in the treatment of increased intracranial pressure in neurosurgical patients

Completed

• Conditions: Increased intracranial pressure; Nervous System Diseases; Brain edema

• Registration Number: ISRCTN62699180
• Lead Sponsor: Martin-Luther-University Halle - Department of Anesthesia and Critical Care (Germany)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-06-24
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Neurosurgical patients >18 years with severe neuronal damage being at risk of increased intracranial pressure (ICP)
2. Cerebral edema - visualized by computed tomography (CT) scan, continuous monitoring of ICP

Exclusion Criteria

Exclusion criteria were elevated ICP due to space occupying lesions with indication for neurosurgical intervention, severe renal failure, metabolic disorders, initial serum sodium >150 mmol/l and initial serum osmolarity >320 mosm/kg

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ICP <15 mmHg

Secondary Outcome Measures

Name	Time	Method
Survival, discharge status