MRI in colon carcinoma: diagnostic value in assessing pathologic regression with therapy

Recruiting

• Conditions: C20; C18.7; C19; Malignant neoplasm of rectum; Sigmoid colon; Malignant neoplasm of rectosigmoid junction

• Registration Number: DRKS00031742
• Lead Sponsor: MU Klinikum der Universität München

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-04-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

? Diagnosis of colorectal carcinoma.
? Request for routine clinical MRI of the liver for staging.
? Treatment plan with future potential resection of the primary (to determine pTRG) and distant metastases, if applicable.

Exclusion Criteria

? Contraindication to administration of buscopan to decrease intestinal motility.
? Non-diagnostic MRI examination of the colon.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the diagnostic accuracy of MR morphological tumor regression grade (mrTRG) compared to pathological tumor regression grade (pTRG).

Secondary Outcome Measures

Name	Time	Method
To investigate the prognostic value of MRI-based findings with overall survival. These include MRI-defined extramural vascular invasion (EMVI), apparent diffusion coefficient (ADC) / IVIM score, and kurtosis score.