Efficacy and safety of Artesunate plus Sulphadoxine-Pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in malaria control center Asadabad in Kunar province of Afghanista
- Conditions
- uncomplicated falciparum malariaInfection - Studies of infection and infectious agents
- Registration Number
- ACTRN12612001049864
- Lead Sponsor
- Research Department, Ministry of Publich Health, Afgahnistan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 88
Age above 4 months, except females aged between 12 and 17 years
Mono-infection with P. falciparum detected by microscopy
Parasitemia 500-100,000 per microliter, asexual forms
Axillary or tympanic temperature greater than 37.5 C or history of fever during the past 24 hours
Ability to swallow oral medication
Ability and willingness to follow protocol procedures and visit schedule
Informed consent from patient or from parent or legal guardian for children under 16 years
Presence of general danger signs of severe malaria in children under 5 years
Mixed or mono-infection with another Palsmodium species
Pregnancy or breastfeeding
Presence of severe malnutrition
Presence of febrile conditions due to diseases other than malaria
Regular medication which may interfere with the antimalarial pharmacokinetics
History of hypersensitivity reactions or contraindications to any study medications.
Unable to or unwilling to take pregnancy test or contraceptives due to social-cultural reason
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method