A 6-week Randomized, Double-blind, Placebo-controlled, Crossover Study to Assess the Effect of Fluticasone 250μg/Salmeterol 50μg Combination (FSC 250/50) on Exertional Dyspnea in Patients With Symptomatic Mild COPD
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Queen's University
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Dyspnea intensity (Borg rating at a standardized time during exercise)
Overview
Brief Summary
Even patients with milder COPD can have significant physiological abnormalities which become more pronounced during exercise, leading to intolerable breathing discomfort (dyspnea). While there is a compelling physiological rationale for the efficacy of inhaled corticosteroid/long-acting bronchodilator combination therapy [i.e., fluticasone 250μg/salmeterol 50μg (FSC250/50)] in moderate to severe COPD, little information is available on the potential impact of this therapy in milder symptomatic disease. This study will be the first to explore mechanisms of dyspnea and activity limitation in milder COPD and will determine if there is a sound physiological rationale for the use of FSC as therapy for this subpopulation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 41 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Stable mild COPD,
- •FEV1/FVC\<0.7 and FEV1\>60% predicted,
- •Activity-related dyspnea (i.e., Baseline Dyspnea Index focal score \<9, MRC dyspnea scale \>2),
- •Cigarette smoking history ≥20 pack-years.
Exclusion Criteria
- •Presence of a significant disease other than COPD that could contribute to dyspnea and exercise limitation,
- •Important contraindications to clinical exercise testing,
- •Use of daytime oxygen,
- •History of Asthma.
Arms & Interventions
FSC 250/50
fluticasone 250μg/salmeterol 50μg combination
Intervention: fluticasone/salmeterol combination (Drug)
Placebo
matched placebo inhaler
Intervention: placebo (Drug)
Outcomes
Primary Outcomes
Dyspnea intensity (Borg rating at a standardized time during exercise)
Time Frame: 6 weeks
Secondary Outcomes
- Exercise endurance time(6 weeks)
- Measurements of small airway function(6 weeks)
- Exercise measurements of ventilation, breathing pattern, operating lung volumes and respiratory mechanics(6 weeks)
Investigators
Dr. Denis O'Donnell
Principal Investigator
Queen's University