A Phase II study of Pemetrexed/Bevacizumab in patients ineligible for platinum-based chemotherapy with untreated Advanced Non-squamous non-small-cell lung cancer (ALCT003)
Phase 2
Recruiting
- Conditions
- on-squamous Non-small cell lung cancer
- Registration Number
- JPRN-UMIN000010805
- Lead Sponsor
- Department of Respiratory Medicine Kyorin Univercity Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Not provided
Exclusion Criteria
1)active double cancer 2)clinically significant infectious disease 3)history of gross hemoptysis (2.5ml) 4)regular use of aspirin 5)history of diverticulitis or clinically significant diverticular disease 6)clinically significant cardiovascular disease and DVT 7)medically uncontrolled hypertension and diabetes 8)active or symptomatic interstitial lung disease 9)Patients with the plan of operation or thoracic irradiation 10)Patients with wound that has not quite healed 11)pregnancy or lactation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method progression free surviaval
- Secondary Outcome Measures
Name Time Method Response rate, Overall survival, QOL,Time to response,Safety,evaluation of thymidylate synthase protein expression