Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation
- Conditions
- Atrial FibrillationAtrial Flutter
- Interventions
- Registration Number
- NCT00412984
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20976
- Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
- Age ≥ 75, previous stroke
- transient ischemic attack (TIA) or Systemic Embolism (SE)
- Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
- Diabetes mellitus or hypertension requiring pharmacological treatment
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 warfarin - 2 apixaban -
- Primary Outcome Measures
Name Time Method Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding). Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding). All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.
- Secondary Outcome Measures
Name Time Method Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group. Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.
Number of Participants With Events of All-Cause Death During the Intended Treatment Period "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding). Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding). Rate of Adjudicated All-Cause Death During the Intended Treatment Period "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding). All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).
Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group. Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding). Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.
Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding). Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.
Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding). For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.
Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group. Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.
Number of Participants With All Bleeding Events During Treatment Period "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group. All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
Rate of All Bleeding Events During Treatment Period "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group. Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.
Trial Locations
- Locations (266)
David Charles Mishkel, Md, Pa
🇺🇸Boca Raton, Florida, United States
Heart Care Center, P.C.
🇺🇸East Syracuse, New York, United States
Elkhart Clinic, Llc
🇺🇸Elkhart, Indiana, United States
Tupelo Neurology Clinic, Pa
🇺🇸Tupelo, Mississippi, United States
Holston Medical Group
🇺🇸Kingsport, Tennessee, United States
Heartplace
🇺🇸Dallas, Texas, United States
Caritas St. Elizabeth'S Medical Center
🇺🇸Boston, Massachusetts, United States
Nmff
🇺🇸Chicago, Illinois, United States
The Methodist Hospital Neurology Institute
🇺🇸Houston, Texas, United States
The Methodist Hospital
🇺🇸Houston, Texas, United States
The Care Group, Llc.
🇺🇸Indianapolis, Indiana, United States
St Francis Medical Group - Indiana Heart Physicians
🇺🇸Indianapolis, Indiana, United States
University Of Minnesota
🇺🇸Minneapolis, Minnesota, United States
The Carl & Edyth Lindner Center For R&E At The Christ Hosp
🇺🇸Cincinnati, Ohio, United States
Bhs Specialty Network, Inc
🇺🇸San Antonio, Texas, United States
Star Clinical Trails
🇺🇸San Antonio, Texas, United States
Electrophysiology Associates, Pc
🇺🇸Colorado Springs, Colorado, United States
New West Physicians Clinical Research
🇺🇸Golden, Colorado, United States
South Denver Cardiology Associates Pc
🇺🇸Littleton, Colorado, United States
Neccr Internal Medicine & Cardiology Associates,Llc
🇺🇸Fall River, Massachusetts, United States
Connecticut Clinical Research, Llc
🇺🇸Bridgeport, Connecticut, United States
Cardio Assoc Of Del Val, P.A.
🇺🇸Sewell, New Jersey, United States
Mary K. Richards, Md Pa
🇺🇸Little Rock, Arkansas, United States
Cardiovascular Institute Of The South
🇺🇸Houma, Louisiana, United States
Washington Va Medical Center
🇺🇸Washington, District of Columbia, United States
Cardiovascular Associates Of The Delware Valley, P.A.
🇺🇸Elmer, New Jersey, United States
Rogue Valley Physicians - Clinical Research Group
🇺🇸Medford, Oregon, United States
Dr. Rajesh Shroff
🇺🇸Hot Springs, Arkansas, United States
William W Backus Hospital
🇺🇸Norwich, Connecticut, United States
Chase Medical Research, Llc
🇺🇸Waterbury, Connecticut, United States
Imperial Calcasieu Medical Group, Llp
🇺🇸Lake Charles, Louisiana, United States
George Washington University Medical Faculty Associates
🇺🇸Washington, District of Columbia, United States
Avera Medical Associates Clinic
🇺🇸Pierre, South Dakota, United States
Stamford Therapeutics Consortium
🇺🇸Stamford, Connecticut, United States
The William W. Backus Hospital
🇺🇸Norwich, Connecticut, United States
Alfieri Cardiology
🇺🇸Newark, Delaware, United States
Internal Medicine Of Greer
🇺🇸Greer, South Carolina, United States
Cardiology Associates Of New Haven,Pc
🇺🇸Guilford, Connecticut, United States
Medical Research Inst, Inc
🇺🇸Slidell, Louisiana, United States
Medical Research Institute, Inc
🇺🇸Slidell, Louisiana, United States
William Beaumont Hospital
🇺🇸Royal Oak, Michigan, United States
Princeton Medical Institute
🇺🇸Princeton, New Jersey, United States
Advanced Cardiovascular Health Specialists, Pc
🇺🇸Livonia, Michigan, United States
St. Charles Health System, Inc.
🇺🇸Bend, Oregon, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Cor Clinical Research, Llc
🇺🇸Oklahoma City, Oklahoma, United States
University Of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Oklahoma Heart Hospital Physicians
🇺🇸Oklahoma City, Oklahoma, United States
Denver Va Medical Center
🇺🇸Denver, Colorado, United States
Aurora Denver Cardiology Associates, P.C.
🇺🇸Denver, Colorado, United States
Clara V. Massey, Md
🇺🇸Mobile, Alabama, United States
Birmingham Heart Clinic P.C.
🇺🇸Birmingham, Alabama, United States
Internal Medicine Physicians Associates, P.C.
🇺🇸Phoenix, Arizona, United States
Southern Arizona Va Health Care System
🇺🇸Tucson, Arizona, United States
Advanced Clinical Reserach Institute
🇺🇸Anaheim, California, United States
Capitol Interventional Cardiology
🇺🇸Carmichael, California, United States
Jacksonville Heart Center, Pa
🇺🇸Jacksonville, Florida, United States
Atlanta Institute For Medical Research, Inc
🇺🇸Decatur, Georgia, United States
Columbus Cardiology Associates Pc
🇺🇸Columbus, Georgia, United States
Jacksonville Heart Center, P.A.
🇺🇸Jacksonville Beach, Florida, United States
Heart & Vascular Center Research, Inc.
🇺🇸Sarasota, Florida, United States
Luis Tami, Md
🇺🇸Hollywood, Florida, United States
St. Vincent'S Ambulatory Care, Inc
🇺🇸Jacksonville, Florida, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
Healthworx
🇺🇸Hollywood, Florida, United States
Melbourne Internal Medicine Associates
🇺🇸Melbourne, Florida, United States
Fox Valley Clinical Research Center, Llc
🇺🇸Aurora, Illinois, United States
Cardiology Consultants
🇺🇸Pensacola, Florida, United States
Columbus Cardiology Associates,Pc
🇺🇸Columbus, Georgia, United States
Loyola University Medical Center
🇺🇸Maywood, Illinois, United States
Lutheran Medical Group, Llc
🇺🇸Fort Wayne, Indiana, United States
Cpt. James A Lovell Federal Health Care Center
🇺🇸North Chicago, Illinois, United States
Premier Healthcare, Llc
🇺🇸Bloomington, Indiana, United States
The Care Group, Llc
🇺🇸Indianapolis, Indiana, United States
Mcfarland Clinic Pc
🇺🇸Ames, Iowa, United States
Cardiology Associates, Inc.
🇺🇸South Bend, Indiana, United States
Midwest Cardiology Associates , P.C.
🇺🇸Overland Park, Kansas, United States
Cardiology Center, Llc
🇺🇸Marrero, Louisiana, United States
Alexandria Cardiology Clinic
🇺🇸Alexandria, Louisiana, United States
Smith, Patel & Amkieh, Llc
🇺🇸Lacombe, Louisiana, United States
Louisiana Heart Center
🇺🇸Slidell, Louisiana, United States
Ventura Cardio. Cond. Med. Group, Inc.
🇺🇸Ventura, Louisiana, United States
Franklin Square Hospital
🇺🇸Baltimore, Maryland, United States
Midatlantic Cardiovascular Associates, Pa
🇺🇸Westminster, Maryland, United States
Central Maine Heart & Vascular Institute
🇺🇸Lewiston, Maine, United States
Clinical Associates Research
🇺🇸Reisterstown, Maryland, United States
Medical College Of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Pentucket Medical Associates
🇺🇸Haverhill, Massachusetts, United States
University Of Missouri
🇺🇸Columbia, Missouri, United States
Lahey Clinic Medical Center
🇺🇸Burlington, Massachusetts, United States
Thoracic And Cardiovascular Healthcare Foundation
🇺🇸Lansing, Michigan, United States
Minneapolis Va Medical Center
🇺🇸Minneapolis, Minnesota, United States
Michigan Heart, P.C.
🇺🇸Ypsilanti, Michigan, United States
North Memorial Health Care
🇺🇸Robbinsdale, Minnesota, United States
Olive Branch Family Medical Center
🇺🇸Olive Branch, Mississippi, United States
Va Southern Nevada Healthcare System
🇺🇸Las Vegas, Nevada, United States
Internal Medical Associates of Grand Island, P.C
🇺🇸Grand Island, Nebraska, United States
Nebraska Heart Institute
🇺🇸Hastings, Nebraska, United States
Internal Medical Associates Of Grand Island, P.C
🇺🇸Grand Island, Nebraska, United States
Comprehensive Clinical Research
🇺🇸Berlin, New Jersey, United States
University Of New Mexico/University Hospital
🇺🇸Albuquerque, New Mexico, United States
Central New Jersey Cardiology
🇺🇸South Plainfield, New Jersey, United States
Cardiovascular Associates Of The Delaware Valley, P.A.
🇺🇸Haddon Heights, New Jersey, United States
Abq Health Partners, Llc
🇺🇸Albuquerque, New Mexico, United States
Albany Assoc. In Cardiology
🇺🇸Albany, New York, United States
Albany Associates In Cardiology
🇺🇸Albany, New York, United States
Suburban Cardiology
🇺🇸Williamsville, New York, United States
Long Island Heart Associates
🇺🇸Mineola, New York, United States
Saratoga Cardiology Associates, Pc
🇺🇸Saratoga Springs, New York, United States
Community Health Care, Inc.
🇺🇸Canal Fulton, Ohio, United States
Jack C. Va Medical Center
🇺🇸Muskogee, Oklahoma, United States
Christopher M. Johnson, D.O.
🇺🇸Bucyrus, Ohio, United States
Asheville Cardiology Associates
🇺🇸Asheville, North Carolina, United States
Plaza Medical Group, Pc
🇺🇸Oklahoma City, Oklahoma, United States
South Oklahoma Heart Research
🇺🇸Oklahoma City, Oklahoma, United States
Toledo Cardiology Consultants
🇺🇸Toledo, Ohio, United States
Family Practice Center Of Wadsworth, Inc.
🇺🇸Wadsworth, Ohio, United States
Castlerock Clinical Research Consultants, Llc
🇺🇸Tulsa, Oklahoma, United States
Lillestol Research Llc
🇺🇸Fargo, North Dakota, United States
St. Charles Health System, Inc
🇺🇸Bend, Oregon, United States
Hillsboro Cardiology Pc
🇺🇸Hillsboro, Oregon, United States
Oregon Medical Group - Clinical Research
🇺🇸Eugene, Oregon, United States
Blair Medical Associates, Inc.
🇺🇸Altoona, Pennsylvania, United States
Abington Medical Specialists
🇺🇸Abington, Pennsylvania, United States
Heritage Cardiology Assoc.
🇺🇸Camp Hill, Pennsylvania, United States
Central Bucks Cardiology
🇺🇸Doylestown, Pennsylvania, United States
Kandra, Fierer, Kuskin Associates
🇺🇸Harrisburg, Pennsylvania, United States
Pivotal Clinical Research, Llc
🇺🇸Hatfield, Pennsylvania, United States
Internal Medicine And Lipid Mgmt.
🇺🇸Erie, Pennsylvania, United States
Lycoming Internal Medicine Inc.
🇺🇸Jersey Shore, Pennsylvania, United States
Guthrie Clinic Ltd.
🇺🇸Sayre, Pennsylvania, United States
Lowcountry Medical Group, Llc
🇺🇸Beaufort, South Carolina, United States
Preferred Primary Care Physicians
🇺🇸Uniontown, Pennsylvania, United States
Guthrie Medical Group, P.C.
🇺🇸Sayre, Pennsylvania, United States
Cardiology Consultants Of Philadelphia
🇺🇸Yardley, Pennsylvania, United States
Amarillo Heart Clinical Research Institute Inc.
🇺🇸Amarillo, Texas, United States
Lowcountry Medical Group
🇺🇸Beaufort, South Carolina, United States
Columbia Heart Clinic
🇺🇸Columbia, South Carolina, United States
Palmetto Nephrology Pa
🇺🇸Orangeburg, South Carolina, United States
S. Carolina Pharmaceutical Research
🇺🇸Spartanburg, South Carolina, United States
Knoxville Heart Group
🇺🇸Knoxville, Tennessee, United States
Volunteer Research Group
🇺🇸Knoxville, Tennessee, United States
Tennessee Center For Clinical Trials
🇺🇸Tullahoma, Tennessee, United States
Corsicana Medical Research, Pllc
🇺🇸Corsicana, Texas, United States
Northwest Houston Cardiology, Pa
🇺🇸Houston, Texas, United States
Covenant Clinical Research, Pa
🇺🇸San Antonio, Texas, United States
Roanoke Heart Institute, Plc
🇺🇸Roanoke, Virginia, United States
Northwest Heart Center
🇺🇸Tomball, Texas, United States
University Of Texas Health Science Center At Tyler
🇺🇸Tyler, Texas, United States
Rockwood Clinic Research Cent.
🇺🇸Spokane, Washington, United States
Aurora Health Care
🇺🇸Milwaukee, Wisconsin, United States
Walla Walla Clinic
🇺🇸Walla Walla, Washington, United States
Lynn N. Smith, Md
🇺🇸Lewisburg, West Virginia, United States
Heart Center, Inc.
🇺🇸Huntsville, Alabama, United States
Jacksonville Cardiovascular Center
🇺🇸Jacksonville, Florida, United States
Alpha Medical Research
🇺🇸Oviedo, Florida, United States
Jacksonville Center For Clinical Research
🇺🇸Jacksonville, Florida, United States
Wellstar Cardiovascular Medicine, Pc
🇺🇸Marietta, Georgia, United States
Cvms Research Institute, Llc
🇺🇸Jupiter, Florida, United States
Research, Inc.
🇺🇸Vero Beach, Florida, United States
Georgia Heart Specialists, L.L.C.
🇺🇸Covington, Georgia, United States
Physicians Regional Medical Group
🇺🇸Naples, Florida, United States
Cardiovascular Specialits, Pc
🇺🇸Atlanta, Georgia, United States
Augusta Cardiology Clinic, P.C.
🇺🇸Augusta, Georgia, United States
Illinois Heart & Lung Research Center, Sc
🇺🇸Normal, Illinois, United States
Fort Wayne Cardiology
🇺🇸Fort Wayne, Indiana, United States
Cardiology Associates, Pc
🇺🇸Binghamton, New York, United States
Huntington Hospital
🇺🇸Huntington, New York, United States
Carolina Cardiology Associates, Pa
🇺🇸High Point, North Carolina, United States
West Chester Cardiology, Pc
🇺🇸West Chester, Pennsylvania, United States
Office Of Dr. Kozinn
🇺🇸Williamsville, New York, United States
Soltero Cardiovascular Research Center
🇺🇸Dallas, Texas, United States
Heart Center Of North Texas
🇺🇸Fort Worth, Texas, United States
Wilford Hall Medical Center
🇺🇸Lackland Air Force Base, Texas, United States
Tyler Cardiovascular Consultants
🇺🇸Tyler, Texas, United States
Sentara York Clinical Research
🇺🇸Norfolk, Virginia, United States
Edward Balli, Md, Pa
🇺🇸Seguin, Texas, United States
Northeast Georgia Heart Center, Pc
🇺🇸Gainesville, Georgia, United States
Clinical Investigation Specialists, Inc
🇺🇸Gurnee, Illinois, United States
Bruce L. Platt, Md
🇺🇸Buffalo, New York, United States
Ricardo Bedoya, M.D.
🇺🇸Jupiter, Florida, United States
Kernodle Clinic, Inc.
🇺🇸Burlington, North Carolina, United States
Niranjan Seshadri, Md
🇺🇸Sarasota, Florida, United States
Akron Cardiology Consultants
🇺🇸Akron, Ohio, United States
Alabama Internal Medicine Pc
🇺🇸Birmingham, Alabama, United States
Cardiovascular Associates, Pc
🇺🇸Birmingham, Alabama, United States
Southwest Heart
🇺🇸Tucson, Arizona, United States
Pima Research Foundation
🇺🇸Tucson, Arizona, United States
Alaska Heart Institute
🇺🇸Anchorage, Alaska, United States
Mobile Heart Specialists, Pc
🇺🇸Mobile, Alabama, United States
Act/Cardiovascular Research Institute
🇺🇸Beverly Hills, California, United States
Escondido Cardiology Associates, Inc.
🇺🇸Escondido, California, United States
La Mesa Cardiac Center, A Medical Group
🇺🇸La Mesa, California, United States
William D. Bowden, D.O.
🇺🇸Healdsburg, California, United States
Coastal Cardiology
🇺🇸Mission Viejo, California, United States
Va Greater Los Angeles Healthcare System
🇺🇸Los Angeles, California, United States
Kenneth W. Carr Md
🇺🇸Oceanside, California, United States
Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
🇺🇸Palm Springs, California, United States
Arrhythmia Consultants Of The Central Coast Medical Group
🇺🇸Santa Barbara, California, United States
Northern California Medical Associates
🇺🇸Santa Rosa, California, United States
Sacramento Heart And Vascular Medical Associates
🇺🇸Sacramento, California, United States
Desert Cardiology Consultants Medical Group, Inc
🇺🇸Rancho Mirage, California, United States
Regional Cardiolody Associates
🇺🇸Sacramento, California, United States
Northern California Research
🇺🇸Sacramento, California, United States
Cardivasclular Consultants Medical Group
🇺🇸Walnut Creek, California, United States
Shiva Heart Center Medical Group
🇺🇸Wildomar, California, United States
Progressive Clinical Research
🇺🇸Vista, California, United States
Bridgeport Hospital
🇺🇸Bridgeport, Connecticut, United States
Medical Specialist Of The Palm Beach
🇺🇸Atlantis, Florida, United States
Miami International Cardiology Consultants
🇺🇸Miami, Florida, United States
Cardiovascular Specialist Of South Florida
🇺🇸Davie, Florida, United States
The Heart And Vascular Institute Of Florida
🇺🇸Saint Petersburg, Florida, United States
Daytona Heart Group
🇺🇸Daytona Beach, Florida, United States
Cardiology Associates Of Fort Lauderdale, P.A.
🇺🇸Fort Lauderdale, Florida, United States
The Heart & Vascular Institute Of Florida
🇺🇸Clearwater, Florida, United States
Broward General Medical Center
🇺🇸Fort Lauderdale, Florida, United States
Florida Heart Associates
🇺🇸Fort Myers, Florida, United States
Community Clinical Research Center
🇺🇸Anderson, Indiana, United States
Central Cardiology Assoc.
🇺🇸Elizabethtown, Kentucky, United States
Cardiology Associates
🇺🇸Canton, Ohio, United States
Owensboro Heart & Vascular
🇺🇸Owensboro, Kentucky, United States
Johns Hopkins Bayview Medical Center
🇺🇸Baltimore, Maryland, United States
Charles River Medical Associates
🇺🇸Natick, Massachusetts, United States
Cardiovascular Specialists Of Central Maryland, P.A.
🇺🇸Columbia, Maryland, United States
Burlington Medical Associates
🇺🇸Billerica, Massachusetts, United States
Sjh Cardiology Associates
🇺🇸Liverpool, New York, United States
Pinehurst Medical Center, Inc
🇺🇸Pinehurst, North Carolina, United States
Eminence Research, Llc
🇺🇸Oklahoma City, Oklahoma, United States
Center For Atrial Fibrillation
🇺🇸Houston, Texas, United States
Southeastern Research Associates, Inc
🇺🇸Anderson, South Carolina, United States
Upstate Cardiology
🇺🇸Greenville, South Carolina, United States
Francisco R. Maislos
🇺🇸Houston, Texas, United States
Regional Medical Center And Diagnostic Clinics
🇺🇸Humble, Texas, United States
Woodlands North Houston Heart Center
🇺🇸Houston, Texas, United States
The University Of Texas Md Anderson Cancer Center
🇺🇸Houston, Texas, United States
North Dallas Research Associates
🇺🇸McKinney, Texas, United States
Dcol Center For Clinical Research
🇺🇸Longview, Texas, United States
North Texas Medical Research
🇺🇸Plano, Texas, United States
Legacy Heart Center
🇺🇸Plano, Texas, United States
The Univ. Of Texas Health Science Ctr. At Tyler
🇺🇸Tyler, Texas, United States
Utah Cardiology P.C
🇺🇸Layton, Utah, United States
Cardiovascular Associates
🇺🇸Virginia Beach, Virginia, United States
Daniel William Gottlieb, Md
🇺🇸Burien, Washington, United States
Cardiology Associates Of Green Bay Ltd-Bellin Hospital
🇺🇸Green Bay, Wisconsin, United States
Daniel W. Gottlieb, Md, Ps
🇺🇸Burien, Washington, United States
Local Institution
🇬🇧Glasgow, United Kingdom
Cardiology Assc. Of Waukesha
🇺🇸Waukesha, Wisconsin, United States
Florida Heart Group
🇺🇸Orlando, Florida, United States
Va Medical Center
🇺🇸Louisville, Kentucky, United States
Norton Cardiovascular Associates
🇺🇸Louisville, Kentucky, United States
Truman Medical Center
🇺🇸Kansas City, Missouri, United States
Saint Luke'S Lipid And Diabetes Research Center
🇺🇸Kansas City, Missouri, United States
Medical University Of South Carolina
🇺🇸Charleston, South Carolina, United States
Midatlantic Cardiovascular Associates, P.A.
🇺🇸Baltimore, Maryland, United States
Medical Research Initiatives
🇺🇸Richmond, Virginia, United States
Florida Research Network, Llc
🇺🇸Gainesville, Florida, United States
New Lexington Clinic, P.S.C.
🇺🇸Lexington, Kentucky, United States
St. Mary'S Hospital
🇺🇸Madison, Wisconsin, United States
St.Mary'S Hospital
🇺🇸Madison, Wisconsin, United States
St. Luke'S Cardiology
🇺🇸Jacksonville, Florida, United States
Buffalo Heart Group, Llp
🇺🇸Buffalo, New York, United States
Bruce L. Platt Md, Pc
🇺🇸Buffalo, New York, United States
Michigan Heart And Vascular Specialists
🇺🇸Petoskey, Michigan, United States
Dali, Sammi
🇺🇸Michigan City, Indiana, United States
Great Lakes Heart Center Of Alpena
🇺🇸Alpena, Michigan, United States
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States