Defining lymphatic drainage of the liver segments in ma

Withdrawn

• Conditions: Liver tumor; 10019815; 10019818

• Registration Number: NL-OMON41745
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 36

Inclusion Criteria

Age > 18 years, capacitated/mentally competent persons, written informed consent, all patients undergoing partial hepatectomy for liver tumors in the UMC Utrecht can be included in this study.

Exclusion Criteria

- Patients undergoing open RFA for a liver tumor without partial hepatectomy will be excluded from this study.
- Patients undergoing robotic- or laparoscopic partial hepatectomy will be excluded from this study.
- Patients with a history of liver surgery including dissection of the hepatoduodenal ligament will be excluded from this study.
- Known allergy for Blue Patente V®, in accordance with the SPC of Blue Patente V® version okt0132013/College ter Beoordeling van Geneesmiddelen
- Minors or incapacitated subjects

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Define the pattern of lymphatic drainage and the draining lymph nodes from<br /><br>each of the liver segments (by peroperative lymphangiography and visual blue<br /><br>dye detection).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Show that the human liver contains functional lymphatic vessels (by<br /><br>immunohistochemistry on resection specimens).<br /><br>- Show that the flow of lymphatic fluid follows segmental anatomy (by<br /><br>immunohistochemistry on resection specimens).</p><br>