Evolution of Cellular and Viral Resistance in HIV-infected Patients With Lymphoma
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Development of multi-drug resistance (in terms of expression of transmembrane transporters and their transcriptional regulators) in HIV-infected patients with lymphoma.
研究概览
简要总结
The study's chief objective is to observe the evolution of cellular (in terms of expression of transmembrane transporters and their transcriptional regulators) and viral resistance (in terms of development of mutations in the HIV genome that may confer resistance to future treatment for HIV) in HIV-infected patients with lymphoma.
详细描述
The study team will take two or three tubes of blood on three occasions during the course of chemotherapy. The total amount of blood required for this research project is 64mL (approximately 4 tablespoons).
This will allow better understanding of the changes that take place in the blood and the HIV virus itself. It is hoped that this will provide new insights that may aid the understanding and treatment of HIV patients with lymphoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The ability to understand and sign a written informed consent form, prior to participation in any screening procedure and must be willing to comply with all study requirements.
- •Documented HIV-1 infection.
- •Diagnosis of lymphoma (with the exclusion of the five subjects that will be controls).
- •On cART or about to start cART as part of clinical routine care before the initiation of chemotherapy.
排除标准
- •Receiving anti-tuberculosis treatment.
结局指标
主要结局
Development of multi-drug resistance (in terms of expression of transmembrane transporters and their transcriptional regulators) in HIV-infected patients with lymphoma.
时间窗: 3 years
次要结局
- Development of mutations in the HIV genome that may confer resistance to future treatment for HIV.(3 years)