Pulmonary Function After Arterial Sleeve Lobectomy

Completed

• Conditions: Lung Cancer, Nonsmall Cell

• Registration Number: NCT04981938
• Lead Sponsor: Centre Hospitalier Régional Universitaire Montpellier

Brief Summary

Lung cancer is the leading cause of cancer death worldwide. Despite the evolution of medical and multimodal treatments, surgical treatment remains the curative management in the localized cancer.

Historically, in central lung tumors, pneumonectomy was the gold standard. Currently, bronchial sleeve lobectomy is recommended as first-line treatment over pneumonectomy when complete resection is possible (Grade 2C).

In the case of pulmonary artery invasion, lobectomy with arterial resection and reconstruction is now an accepted option for central localized cancer.

Despite surgical challenge, arterial sleeve lobectomy is oncologically comparable with pneumonectomy while avoiding the high morbi-mortality.

Indeed, this surgery has shown better results than pneumonectomy in terms of overall survival, post-operative mortality, and quality of life.

Initially performed in patients with impaired cardio-pulmonary reserves, this parenchymal sparing procedure can be realised in all patients, when anatomical conditions allow a complete resection.

In the literature, no study has yet specifically investigated postoperative respiratory function after arterial sleeve lobectomy.

The investigators designed a retrospective monocentric study at the University Hospital of Montpellier on 81 lobectomies with pulmonary artery sleeve resection for lung cancer, from January 2001 to December 2020.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-07
• Study Start: 2021-07-22
• Study First Submitted: 2021-07-23
• Study First Submitted QC: 2021-07-23
• Study First Posted: 2021-07-29
• Primary Completion: 2021-07-31
• Study Completion: 2021-09-01
• Last Update Submitted: 2021-09-14
• Last Update Posted: 2021-09-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

• all major lung resection with pulmonary artery reconstruction for lung cancer
• from January 2001 to December 2020 at University Hospital of Montpellier
• patient > 18 years

Exclusion Criteria

0

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Impact of pulmonary artery reconstruction on perfusion on the remaining lung lobe (ventilation/perfusion scan)	2001-2020	Comparison of perfusion data on pre and post operative ventilation/perfusion scan

Secondary Outcome Measures

Name	Time	Method
pulmonary artery reconstruction patency	2001-2020	Patency data of the arterial reconstruction (thoracic angioscan)
Impact of pulmonary artery reconstruction on pulmonary function	2001-2020	Comparison of post operative predicted FEV1 to post operative FEV1
Pulmonary function according to the type of reconstruction	2001-2020	Comparison of the results (FEV1 ans patency) according to the type of reconstruction

Trial Locations

Locations (1)

NGUYEN; 🇫🇷 Montpellier, France