The Effect of PPI Therapy on the Result of Helicobacter Pylori Diagnostic Tests
- Conditions
- Helicobacter Pylori
- Registration Number
- NCT01278901
- Lead Sponsor
- Rabin Medical Center
- Brief Summary
STUDY PROTOCOL:
The study will include 30 patients ages 18-80y that had a gastroscopy for various reasons. The patients should not be on PPI therapy . If during the gastroscopy there are some pathologies that require a second look endoscopy after some weeks of therapy (ulcers or esophagitis), the investigators will repeat the gastroscopy within a month.
During the first gastroscopy a biopsy will be taken for histological examination and for a rapid urease test and an urea breath test will be done soon after the procedure.
If one of the tests is positive the investigators postulate that the Helicobacter pylori is actually present.
After the gastroscopy the patient is given a full dose of PPI (as indicated) and helicobacter tests are repeated in the next endoscopy (under PPI therapy) . Any positive test that become negative in the second endoscopy is considered false negative.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
- Cohort of helicobacter pylori positive patients undergoing EGD for different indications and not treated with PPI-
- Patients younger than 18 years and older than 80 years
- Severe background diseases
- Previous eradicated helicobacter pylori infection
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect of PPI treatment on helicobacter pylori diagnostic tests 1 month of therapy
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Gastroenterology, Rabin Medical Center
🇮🇱Petach Tikva, Israel