The Effect of PPI Therapy on the Result of Helicobacter Pylori Diagnostic Tests
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Effect of PPI treatment on helicobacter pylori diagnostic tests
研究概览
简要总结
STUDY PROTOCOL:
The study will include 30 patients ages 18-80y that had a gastroscopy for various reasons. The patients should not be on PPI therapy . If during the gastroscopy there are some pathologies that require a second look endoscopy after some weeks of therapy (ulcers or esophagitis), the investigators will repeat the gastroscopy within a month.
During the first gastroscopy a biopsy will be taken for histological examination and for a rapid urease test and an urea breath test will be done soon after the procedure.
If one of the tests is positive the investigators postulate that the Helicobacter pylori is actually present.
After the gastroscopy the patient is given a full dose of PPI (as indicated) and helicobacter tests are repeated in the next endoscopy (under PPI therapy) . Any positive test that become negative in the second endoscopy is considered false negative.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cohort of helicobacter pylori positive patients undergoing EGD for different indications and not treated with PPI-
排除标准
- •Patients younger than 18 years and older than 80 years
- •Severe background diseases
- •Previous eradicated helicobacter pylori infection
结局指标
主要结局
Effect of PPI treatment on helicobacter pylori diagnostic tests
时间窗: 1 month of therapy
次要结局
未报告次要终点