How can we treat photophobia in migraine?A functional imaging investigation of two opposing concepts
- Conditions
- G43.9Migraine, unspecified
- Registration Number
- DRKS00007739
- Lead Sponsor
- niversitätsklinik für NeurologieMedizinische Universität Wien
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Patients:
o Migraine without aura according to the criteria of ICHD-III beta
o Migraine present on 1 and 4 days per month in the 3 months preceding study
inclusion
o Intensity of interictal sensitivity to light 2 – 6 on a numeric rating scale with
range 0-10
o Intensity of ictal sensitivity to light >4 on a numeric rating scale a numeric
rating scale with range 0-10
Controls:
o Matched for age, sex, education and socioecomic status to patients
o No personal or family history of migraine
o sensitivity to light <2 on a numeric rating scale
o Any other recurrent current or previous headache disorder apart from infrequent
tension-type headache
o Current or previous medication overuse
o Pregnancy
o Photosensitive epilepsy (excluded by a routine EEG)
o Other current or previous brain disorders
o Ophthalmological disorders relevant to the study
o Psychiatric disorders relevant to the study
o Other diseases relevant to the study including circadian rhythm disorders
o Regular intake of centrally acting compounds including prophylactic medication for
headache in the preceding three months
o Shift and / or night work
o Regular stay in unusually dark or bright environments
o Light therapy within the preceding 3 months
o Strategies to avoid exposure to light within the preceding 3 months
o Claustrophobia
o Metallic implants preventing fMRI
o Current or history of substance abuse
o Any other fMRI contraindications
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a. Difference in mean total (i.e. ictal and interictal) sensitivity to light in the week after<br>the intervention (days 8 – 14) between light exposure and light deprivation in<br>patients with migraine<br><br>b. Change in mean total sensitivity to light in the week after light exposure (days 8 –<br>14) compared to baseline (days -7 – -1) in patients with migraine<br><br>c. Change in mean total sensitivity to light in the week after light deprivation (days 8<br>– 14) compared to baseline (days -7 – -1) in patients with migraine
- Secondary Outcome Measures
Name Time Method a. Differences in mean interictal and mean ictal sensitivity to light in the week after<br>the intervention (days 8 – 14) between light exposure and light deprivation in<br>patients with migraine<br><br>b. Changes in mean interictal and mean ictal sensitivity to light in the week after light<br>exposure (days 8 – 14) compared to baseline (days -7 – -1)