Association Between Gene Polymorphism of IL17 and IL 23 in Patients With COVID 19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- genotyping of IL 23
研究概览
简要总结
rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins. These pleiotropic cytokines are secreted at the region of inflammation and released into the circulation by a variety of different cell types, including macrophages, lymphocytes, endothelial cells, epithelial cells during sepsis and acute organ injuries. There has recently found a number of studies reporting that the cytokine storms take part in the course of COVID-19
详细描述
Aim Of The Study
- To evaluate if there is an association between the IL-17, IL-23 gene polymorphism in Patients With COVID 19 by real-time PCR
- To measure the serum level of IL17 by ELISA in COVID 19 patients by ELISA.
- To detect if there is an association between gene polymorphism of IL17 and IL23 and severity of a condition in patients with COVID 19 Study design: a cross-sectional study.
The blood samples will be collected from patient records in COVID19 isolation hospitals in sohag governorate and isolation department in sohag university hospitals.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with Covid19 positive PCR
排除标准
- •Patients with Covid19 clinical criteria not confirmed by PCR
结局指标
主要结局
genotyping of IL 23
时间窗: 3-6-2021 to 30-8-2021
real time pcr detection of different genotypes
genotyping of IL 17
时间窗: 3-6-2021 to 30-8-2021
real time pcr detection of different genotypes
estimation of serum level of IL 17
时间窗: 3-6-2021 to 30-8-2021
measuring serum level of IL 17 by ELISA
次要结局
未报告次要终点
研究者
Noha Saber Shafik
lecturer
Sohag University