Risk Factors for Staphylococcus Aureus Surgical Site Infections in Orthopedic and Trauma Surgery

• Conditions: Staphylococcus Aureus; Traumatology; Orthopedic Disorder; Surgical Wound Infection

• Registration Number: NCT03040960
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

The most commonly identified organism for Surgical Site Infection (SSI) in orthopedic surgery is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known. The aim of this study was to evaluated the incidence rate of S. aureus SSI over the years and risk factors of these infections in a french University Hospital.

Detailed Description

Surgical site infections (SSI) in orthopedic surgery are responsible for reduced quality of life, increased length of hospital stay and costs. The most commonly identified organism is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known.The aim of this study was to evaluate the incidence rate trend of S. aureus SSI over the years and risk factors of theses infections in a french University Hospital.

The knowledge obtained by this study will enable identification of the surgical patients most at risk of developping S. aureus SSI, and who would probably benefit most from new interventions given prophylactically and specifically to prevent S. aureus infections.

Study Timeline

• Study Start: 2016-08
• Study First Submitted: 2017-01-31
• Study First Submitted QC: 2017-01-31
• Study First Posted: 2017-02-02
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-10
• Last Update Posted: 2017-10-11
• Primary Completion: 2018-08
• Study Completion: 2018-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• orthopedic or traumatology surgeries performed in Grenoble University Hospital,
• from january 1st 2012 to april 30th 2015,
• the subject is undergoing one of the following surgical procedures : knee and hip arthroplasties, osteosynthesis of proximal femur and other osteosynthesis except skull and spine.
• the subject is 16 years of age or older

Exclusion Criteria

• non orthopedic or trauma surgery performed in Grenoble University Hospital,
• spine surgeries,
• surgeries of the hand, scaphoid and carpal bones.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Risk factors of S. aureus surgical site infections.	up to 1 year following surgery	univariate analysis of potential risk factors. Data with p value less than 0.1 were included in a logistic regression model

Secondary Outcome Measures

Name	Time	Method
The incidence rate trend of S. aureus SSI over the year.	from january 1st 2012 to april 30th 2015	linear regression slope test of S. aureus SSI incidence rates by years

Trial Locations

Locations (1)

University Hospital, Grenoble Alpes; 🇫🇷 Grenoble, France