The Effect of Nutrition for the Colorectal Cancer Patients Receiving Chemotherapy-randomized Controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Colorectal Cancer
- Sponsor
- Chang Gung Memorial Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Assessment of adverse event
- Last Updated
- 5 years ago
Overview
Brief Summary
We use clinical trial to explore the effect of nutrition support in colorectal cancer patients receiving postoperative adjuvant chemotherapy.
Detailed Description
Colorectal cancer is the most common cancer in Taiwan. Side effects induced by postoperative adjuvant chemotherapy will affect nutrition status and may delay treatment and affect prognosis. Sarcopenia may be noted in some patients and increase the toxicities of chemotherapy. The studies of intervention include nutrition consultant and treatment like protein, fish oil or Vitamin D supplement. Premium amino acids include multiple amino acids and organic Selenium and have effect in inhibition of tumor proliferation according to colorectal cancer cell and animal experiments.
Investigators
Wan-Hsiang Hu
Attending physician
Chang Gung Memorial Hospital
Eligibility Criteria
Inclusion Criteria
- •Age \> 20
- •Radical operation for stage III and stage II with high risk colorectal cancer
- •Agree to join the trial and sign the informed consent form
Exclusion Criteria
- •Unable to receive chemotherapy
- •Unstable vital sign
- •Not suitable after evaluation by Principal Investigator
Outcomes
Primary Outcomes
Assessment of adverse event
Time Frame: 2 weeks after chemotherapy
Evaluation of adverse event(Grade 1-4) between control group and experimental group before every chemotherapy(total 12 times)
2)Nutrition assessment
Time Frame: 2 weeks after chemotherapy
pre-albumin level between two group before every chemotherapy(total 12 times)
1)Sarcopenia assessment muscle power
Time Frame: At 12th cycle of chemotherapy (each cycle is 2 weeks).
1-2)Assessment with Grip strength(Kg)
3)Sarcopenia assessment
Time Frame: At 12th cycle of chemotherapy (each cycle is 2 weeks).
3-2)Assessment with speed(m/s)
1)Nutrition assessment
Time Frame: 2 weeks after chemotherapy
albumin level between two group before every chemotherapy(total 12 times)
2)Sarcopenia assessment muscle power
Time Frame: At 12st cycle of chemotherapy (each cycle is 2 weeks).
2-2)Assessment with ASM/heigh2(Kg/m2)
5)Sarcopenia assessment
Time Frame: At 12th cycle of chemotherapy (each cycle is 2 weeks).
5-2)Assessment with abdominal CT
4)Sarcopenia assessment
Time Frame: At 12th cycle of chemotherapy (each cycle is 2 weeks).
4-2)Assessment with DXA(g/cm2)