NCT02449317已完成不适用
Bioimpedance Analysis Guided Volume Expansion for the Prevention of Contrast
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 56
- 主要终点
- serum creatinine at 48-72 hours after contrast administration
研究概览
简要总结
Bioelectrical impedance analysis guided volume expansion for the prevention of contrast induced-acute kidney injury
详细描述
Compared bioelectrical impedance analysis guided hydration therapy versus standard hydration for the prevention of contrast induced-acute kidney injury
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-90 yr
- •Chronic kidney disease stage 3 & 4 (eGFR 15-60 ml/min/m2)
- •elective cardiac catheterization
排除标准
- •Contrast media administration in the past 14 days
- •congestive heart failure (NYHA III-IV, ascites , pleuropericardial effusion ,severe valvular heart disease
- •Kidney transplant status or RRT
- •Emergency cardiac catheterization
- •Allergy to radiographic contrast media
- •Unstable renal function (change in serum creatinine ≥ 0.5 mg/dl or 25% within 14 days prior to the study
- •Not inform consent
- •left ventricular ejection fraction < 40 %
- •Liver cirrhosis child B or C
- •Dosage of angiotensin-converting enzyme inhibitor /angiotensin II receptor blocker changed in past 2 wk
研究组 & 干预措施
Control
Other
standard hydration : 7.5% Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV 1 ml/kg/hr in 6 hours
干预措施: standard hydration (Other)
Bioimpedance guided
Experimental
Bioelectrical impedance analysis guided hydration therapy : 7.5% Sodium bicarbonate 150 ml + 5% dextrose in water 850 ml IV in 6 hours rate was adjusted regarding to extracellular water/total body water
- extracellular water/total body water < 0.36 : 4 ml/kg/hr
- extracellular water/total body water 0.36-0.4 : 2 ml/kg/hr
- extracellular water/total body water > 0.4 : 1 ml/kg/hr
干预措施: Bioimpedance guided (Other)
结局指标
主要结局
serum creatinine at 48-72 hours after contrast administration
时间窗: 48-72 hr
Acute kidney injury
次要结局
- serum creatinine at 2 weeks after contrast administration(2 weeks)
研究者
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