NCT04151095CompletedNot Applicable
Examining The Effect of Blood Flow Restricted Aerobic Training on Citrate Synthase Activity in Young Healthy Adults
Brendon Gurd, PhD1 site in 1 country19 target enrollmentStarted: May 6, 2019Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 19
- Locations
- 1
- Primary Endpoint
- Citrate Synthase
Study Overview
Brief Summary
This parallel-arm trial study investigates the effects of restricting arterial blood flow during cycling exercise on citrate synthase. Participants will be randomized to either a blood flow restricted or non-blood flow restricted exercise training group. Both groups will complete seven, 30-minute exercise sessions over a 14-day period.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Investigator, Outcomes Assessor)
Masking Description
Allocation concealment, assessor blinding
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •3 hours of physical activity per week
- •No previous cycling training
- •No concurrent involvement in another training program
- •Body mass index < 30 kg/m2
Exclusion Criteria
- •Presence of cardiovascular disease
- •Presence of metabolic disease
- •Taking regular oral medication
- •Current smoker
Arms & Interventions
BFR
Experimental
Intervention: BFR Exercise Training (Other)
CTL
Experimental
Intervention: CTL Exercise Training (Other)
Outcomes
Primary Outcomes
Citrate Synthase
Time Frame: 3 days prior to start of exercise training and 3 days after completing exercise training
Fold change in citrate synthase maximal activity
Secondary Outcomes
- Heart rate (HR)(Every 5 minutes during each of the 7, 30-minute exercise sessions)
- Rating of perceived exertion (RPE)(Every 5 minutes during each of the 7, 30-minute exercise sessions)
- Nuclear Factor, Erythroid 2 Like 2 (NFE2L2)(3 days before training to 3 days after training)
- Transcription factor A, mitochondrial (TFAM)(3 days before training to 3 days after training)
- Maximal oxygen consumption (VO2peak)(3 days before training to 3 days after training)
- Revolutions per minute (RPM)(Every 5 minutes during each of the 7, 30-minute exercise sessions)
- Blood [lactate](During all exercise sessions at 10 and 30 minutes)
- Cytochrome c oxidase (COX)(3 days before training to 3 days after training)
- Electromyography (EMG)(Throughout each of the 7, 30-minute exercise sessions)
- Near-infrared spectroscopy (NIRS)(Throughout each of the 7, 30-minute exercise sessions)
- Nuclear respiratory factor, 1 (NRF1)(3 days before training to 3 days after training)
Investigators
Brendon Gurd, PhD
Associate Professor
Queen's University
Study Sites (1)
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